CHAPTER 6

Biopharmaceutical Factors

Author: Michael Makoid Reviewer: Phillip Vuchetich

OBJECTIVES After successfully completing this chapter, the student shall understand: 1.

Physiology and machanisms of absorbtion

2.

Effects of diffusion, cardiac output / blood perfusion, physical properties of the drug and body on distribution

3.

Biotransformation, first pass effect, and clearance

4.

Renal, biliary, mammary, salivary, other forms of excretion.

5.

identify the effects of physiological changes with age, sex, and disease on the absorption, distribution, metabolism, and excretion of a drug.

Basic Pharmacokinetics

REV. 99.4.25

Copyright © 1996-1999 Michael C. Makoid All Rights Reserved

http://kiwi.creighton.edu/pkinbook/

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