BPH70112 B.Pharmacy (VII Semester) Examinations - December,2017 (Regulation 2012-13) Regular / Supplementary

Paper-I: Pharmaceutics-III (Biopharmaceutics, Pharmacokinetics & New Drug Delivery Systems) Time : Three Hours

Maximum Marks: 70

Answer all the questions. All questions carry the equal marks.

(5x14=70M)

1. a) Explain the role of anatomical and physciological considerations of GIT in durg absorption. b) What are the mechanisms of drug transport and write in detail about active transport. (OR) c) Explain the pH-partition hypothesis and mention its limitations. d) Write about official dissolution testing methods. 2. a) Discuss about excretion pathways of drugs mentioning their relative merits. b) Write about plasma protein binding and its implications. (OR) c) Explain phase 1 biotransformation reactions. d) Explain the distribution of drugs. 3. a) Explain the significance of compartment modeling and discuss about one compartment model. b) Explain the methods for calculation of renal clearance. (OR) c) What are the reasons for non-linearity? How non-linearity is detected? Give two examples of drugs following non-linear kinetics. d) Write about double reciprocal plot and its advantages and disadvantages. 4. a) Explain the formulation and evaluation of intrauterine device. b) Write about approaches for controlling drug release from sustained release products. (OR) c) What are microcapsules? Mention their advantages. Explain the method of interfacial polymerization. d) Write the need for calculation of loading and maintenance doses. 5. a) Explain the design of controlled drug delivery. b) Write about the methods for preparation of liposomes. (OR) c) Mention the advantages of transdermal drug delivery. Write about the qualities of drugs suitable for these systems. d) Write about resealed erythrocytes.

BPH70312 B.Pharmacy (VII Semester) Examinations - December,2017 (Regulation 2012-13) Regular / Supplementary

Paper-II: Pharmacology-II Time : Three Hours

Maximum Marks: 70

1. a) Classify anti arrythmic drugs with examples. Explain their mechanism of action. (OR) b) Classify anti platelet drugs with examples. Explain their mechanism of action. 2. a) Discuss about the pharmacology of beta agonists. Add a note on anti tussives. (OR) b) Discuss about the biosynthesis and functions of prostaglandins. 3. a) Discuss about the chemotherapy of tuberculosis. (OR) b) Classify anti-cancer drugs with examples. Explain their mechanism of action. 4. a) Discuss the pharmacology of oral hypoglycemic agents. (OR) b) Discuss about glucorticoids and mineralocorticoids. 5. a) Discuss about any bioassay methods for insulin. (OR) b) Discuss about the diagnosis and treatment of organophosphorous poisoning.

BPH70512 B.Pharmacy (VII Semester) Examinations - December,2017 (Regulation 2012-13) Regular / Supplementary

Paper-III: Pharmaceutical Analysis-II Time : Three Hours

Answer all the following. All questions carry equal marks. 1.

Maximum Marks: 70

(5x14=70M)

With a neat sketch explain the working principle of IR spectrocopy. With an example how IR spectrum helps in structure analysis of an organic compound. (Or) With a neat block diagram explain the principle, instrumentation and applications of flame photometry.

2. a) Write a note on i) Reference electrodes ii) Dead stop end-point method (Or) b) What is linear scale polarography? Discuss the factors affecting limiting current in polarography. c) Explain how angle of rotation of compound is determined by using polarimeter. 3.

Write short notes on i) Experimental techniques in TLC ii) Reagents used for developing TLC (Or) Write in brief on a) detectors used in GC b) Stationery phases used in GC

4.

Explain the principle involved in HPLC. Discuss the role of particle size and pressure on resolution of a mixture. Add a note on applicatons of HPLC. (Or) Different HPLC and HPTLC. Explain how HPTLC is used for quality assessment of pharmaceuticals? Add a note on preparation of HPTLC plates.

5.

With a neat sketch explain the principle and working of NMR spectroscopy instrument. (Or) i) Differentiate DTA and DSC. ii) Instrumentation and working RIA

BPH70712 B.Pharmacy (VII Semester) Examinations - December,2017 (Regulation 2012-13) Regular / Supplementary

Paper-IV: Industrial Management and Pharmaceutical Marketing Time : Three Hours

Maximum Marks: 70

Answer all the following. All questions carry equal marks.

(5x14=7O)

1.

What do you understand by the concept of Management? What are its functions? (or) What do you understand by the concept of organization? What are the various elements involved in it?

2.

Outline the factors influencing drug store location. (or) Write briefly about the following: i) Product layout ii) Process layout

3.

What is productivity? Discuss the problems of productivity. (or) Briefly explain about various on the job and off the job methods of training.

4.

Define ‘Marketing’. What are the various approaches to the study of Marketing? (or) Examine the need for advertising with particular reference to pharmaceutical products.

5.

Define ‘Costing’. Briefly explain about the principles of Costing. (or) What is a journal? Distinguish between journal and ledger.