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Cell Proliferation Volume 38 Issue 3 Page 153 - June 2005 To cite this article: P. W. Sylvester, S. J. Shah, D. T. Haynie, K. P. Briski (2005) Effects of ultra-wideband electromagnetic pulses on pre-neoplastic mammary epithelial cell proliferation Cell Proliferation 38 (3), 153–163. doi:10.1111/j.1365-2184.2005.00340.x Prev Article Next Article

Original Article

Effects of ultra-wideband electromagnetic pulses on pre-neoplastic mammary epithelial cell proliferation P. W. Sylvester* S. J. Shah*D. T. Haynie† K. P. Briski* *School of Pharmacy, University of Louisiana at Monroe, Monroe, LA; †Biomedical Engineering and Physics, Center for Applied Physics Studies, Louisiana Tech University, Ruston, LA Paul W. Sylvester, School of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209–0470, USA. Tel.: 318-342-1958; Fax: 318-342-1606; E-mail: [email protected] Abstract Abstract. Electromagnetic ultra-wideband pulses (UWB) or nanopulses, are generated by a wide range of electronic devices used in communications and radar technology. However, the specific effects of nanopulse exposure on cell growth and function have not been extensively investigated. Here, studies have been conducted to determine the effects of prolonged exposure to nonionizing, low to moderate intensity nanopulses on the growth of preneoplastic CL-S1 mammary epithelial cells in vitro. Cells were grown in culture and maintained in serum-free defined medium containing 10 ng/ml EGF and 10 µg/ml insulin as comitogens. Studies showed that 0.25–3.0 h exposure to nanopulses of 18 kV/m field intensity, 1 kHz repetition rate and 10 ns pulse width had no effect on CL-S1 cell growth or viability during the subsequent 72-h culture period. However, exposure to similar nanopulses for prolonged periods of time (4–6 h) resulted in a significant increase in cell proliferation, as compared to untreated controls. Additional studies showed

...ell Synergy  Cell Prolif, Volume 38 Issue 3 Page 153  June 2005 (Article Abstract).htm 26/02/2007

(Blackwell Synergy  Cell Prolif, Volume 38 Issue 3 Page 153  June 2005 (Article Abstract 2 ‫ מתו‬2 ‫ד‬

that nanopulse exposure enhanced CL-S1 cell growth when cells were maintained in media containing only EGF, but had no effect on cells maintained in defined media that were mitogen-free or containing only insulin. Studies also showed that the growth-promoting effects of nanopulse exposure were associated with a relatively large increase in intracellular levels of phospho-MEK1 (active) and phospho-ERK1/2 (active) in these cells. These findings demonstrate that prolonged exposure to moderate levels of UWB enhanced EGF-dependent mitogenesis, and that this growth-promoting effect appears to be mediated by enhanced activation of the mitogenactivated protein kinase (MAPK) signalling pathway in pre-neoplastic CL-S1 mammary epithelial cells.

This article is cited by: This article is cited by the following articles in Blackwell Synergy and CrossRef  A. L. Garner, Y. Y. Lau, D. W. Jordan, M. D. Uhler and R. M. Gilgenbach

. (2006) Implications of a simple mathematical model to cancer cell population dynamics. Cell Proliferation 39:1, 15–28 Abstract Abstract and References Full Text Article Full Article PDF  Tripura Bojjawar, Madan Jalari, Eric Aamodt, Matthew F. Ware, Donald T. Haynie. (2006) Effect of electromagnetic nanopulses onC. elegans fertility. Bioelectromagnetics 27:7, 515 CrossRef This Article Abstract References Full Text HTML Full Text PDF (239 KB) Rights & Permissions Search In Synergy PubMed (MEDLINE) CrossRef By author P. W. Sylvester S. J. Shah D. T. Haynie K. P. Briski

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Jun 28, 2005 - 318-342-1958; Fax: 318-342-1606; E-mail: [email protected] ... levels of phospho-MEK1 (active) and phospho-ERK1/2 (active) in these cells.

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