European Melioidosis Congress 2015 26th & 27th March, Downing College Cambridge Day 2 Friday 27th March, DAY 2 8.55

Notices (Sharon Peacock)

Session 3: Pathogenesis & Immunology Chair: Professor Rick Titball, University of Exeter, UK

9.00

T cell immunity in melioidosis Professor Danny Altmann, Imperial College, London, UK

9.30

What can TraDIS tells us about B. pseudomallei pathogenesis? Professor Brendan Wren, London School of Hygiene & Tropical Medicine, London, UJK

10.00

Autotransported (type V secreted) proteins of Burkholderia pseudomallei and their role in biofilm formation, serum resistance and pathogenesis. Dr Natalie Lazar Adler, University of Leicester, UK

10.10

Programmed Death-Ligand 1 on Burkholderia pseudomallei infected human polymorphonuclear neutrophils impairs T cell functions Dr Ganjana Lertmemongkolchai, Khon Kaen University, Thailand

10.20

Identification of Burkholderia pseudomallei Type Three Secreted Effector Proteins using Quantitative Proteomics Dr Jo Stevens, University of Edinburgh, UK

10.30

TEA & COFFEE

Session 4: Moderated poster walks

11.00 -

Poster session

13.00

13.00

LUNCH

Session 5: Vaccines and Therapeutics Chair: Dr Alex Hoffmaster, Centers for Disease Control, US

13.55

Announcement and presentation of three poster prizes Sharon Peacock

14.00

Progress in animals models and vaccines Professor Alfredo Torres, University of Texas Medical Branch Galveston, US

14.30

New B. pseudomallei resistance mechanisms & novel therapies for melioidosis Professor Herbert Schweizer, Emerging Pathogens Institute, University of Florida, US

15.00

Importance of Adjuvants in the Development of Melioidosis Subunit Vaccine Formulations Dr. Paul Brett, University of South Alabama

15.10

Bacterial disarmament: DSB proteins as an anti-virulence target in Burkholderia pseudomallei Dr Roisin Mcmahon, University of Queensland

15.20

A study of human immunity to protein antigens, following exposure to Burkholderia species, for vaccine candidate selection Dr Susanna Dunachie, Mahidol-Oxford Tropical Medicine Research Unit, Thailand

15.30

TEA/COFFEE

Session 6: Young Investigator presentations Chair: Dr Susanna Dunachie, Mahidol-Oxford Tropical Medicine Research Unit, Thailand

16.00

The gut microbiota as a possible modulator of innate immunity during melioidosis Ms Jacqueline Lankelma, Academic Medical Center, University of Amsterdam, The Netherlands

16.10

Diagnostic accuracy and utility of B. pseudomallei antigen-detecting RDTs in diagnosis of melioidosis in Laos Dr Kate Woods, Public Health England & Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Lao PDR

16.20

Heme oxygenase-1 (HO-1) and carbon monoxide (CO) contribute to Burkholderia pseudomallei growth in macrophages and during murine melioidosis Ms Claudia Stolt, Friedrich Loeffler Institute of Medical Microbiology, Greifswald, Germany

16.30

Sequence- and Structure-based immunoreactive epitope discovery for Burkholderia pseudomallei flagellin Mr Arnone Nithichanon, Khon Kaen University, Thailand

16.40

Burkholderia pseudomallei –Refining Clinical Breakpoints: a Study of Minimum Inhibitory Concentration by Test Method, Treatment Outcome, and Comparison With Available PK/PD Data. Dr Samuel Maloney, The Townsville Hospital, Queensland, Australia

16.50

Host-Adaptation of Burkholderia pseudomallei alters Metabolism and Virulence Factors: a Global Comparative Proteomic Analysis Dr Vanitha Mariappan, University of Malaya, Malaysia

17.00

Closing comments Sharon Peacock

Day 2 — European Melioidosis Congress 2015 -

Chair: Professor Rick Titball, University of Exeter, UK. 9.00 ... Ms Jacqueline Lankelma, Academic Medical Center, University of Amsterdam, The Netherlands.

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