Symposium Invitation

for Alzheimer’s and Parkinson’s diseases November 1, 2016 Biogen, Building 1 250 Binney Street Cambridge, MA

Organized by Nancy Kopell and Mihály Hajós

All attendees need to register by sending email to: [email protected] The symposium is free for academic scientists; for scientists at pharmaceutical and biotech companies there is a registration fee of $500. Space is limited.

The topic of this symposium will be the potential application of various neurophysiological markers of brain dynamics as potential translational biomarkers in neurodegenerative drug discovery. We expect a critical discussion on the applications of these markers to evaluate disease progression and disease-modification therapies of Alzheimer’s and Parkinson’s disease. Lectures 9:00 a.m. – 5:15 p.m. Nancy Kopell, PhD Dept. of Mathematics, Boston University Introduction to brain network oscillations in health and disease

John T. Gale, PhD Dept. of Neuroscience and Center for Neurological Restoration, Cleveland Clinic Pathophysiology of the human basal ganglia in Parkinson disease Judith Walters, PhD National Institute of Neurological Disorders and Stroke, NIH, Bethesda What’s the potential of LFPs as biomarkers in Parkinson’s disease? Lessons from the hemi-parkinsonian rat Michelle McCarthy, PhD Dept. of Mathematics, Boston University Striatal cholinergic tone as a key modulator of beta frequency oscillations and parkinsonian-like motor deficits Jean-François Gagnon, PhD Psychology Department, Université du Québec à Montréal Electroencephalographic prodromal markers of Parkinson’s disease and dementia

Sponsored by

Bryce A. Mander, PhD Sleep and Neuroimaging Laboratory University of California, Berkeley Linking EEG, sleep, Aβ and Alzheimer’s disease B. Platt, PhD Biomedical Sciences, University of Aberdeen, Scotland Age-related changes in sleep and EEG profiles in mouse models of Alzheimer’s disease Chantal Stern, PhD Cognitive Neuroimaging Laboratory, Boston University Neuronal network characteristics in Parkinson’s and Alzheimer’s disease Michael E. Hasselmo, PhD Dept. of Psychological and Brain Sciences, Boston University, Modeling cortical dynamics that may underlie hippocampal hyperactivation in Alzheimer’s disease

Reception and Poster session 5:30 – 8:00 p.m. Poster session will provide opportunities for local scientists to present their neurodegeneration-related neurophysiological studies, and to develop collaborations (send poster title with registration).