PG – 420

*PG420*

Fourth Semester M.Sc. Degree Examination, June/July 2014 (NS) (2011 Scheme) APPLIED GENETICS Paper – 403 : Molecular Medicine Time : 3 Hours

Max. Marks : 80

Instructions : 1) Answer all the Parts. 2) Draw diagrams wherever necessary. PART – A Write short notes on the following :

(5×2=10)

1. DMD 2. SCID 3. Leukemia 4. RNomics 5. Ribozyme PART – B Write critical notes on the following :

(5×8=40)

6. DNA vaccines OR Epigenetic phenomenon in yeast. 7. Cystic fibrosis OR Chromatin remodelling 8. Stem cell OR Tissue engineering P.T.O.

*PG420*

PG – 420 9. RNA silencing in Plants OR Alternative splicing 10. Epigenetic regulators of pluripotency OR Trithorax proteins PART – C Answer any two of the following :

(2×15=30)

11. Explain the principles and strategies of gene therapy with a note on its applications. 12. Discuss the moelcular aspects of nuclear reprogramming in stem cells. 13. Write an explanatory note on micro RNAs and its functions. 14. Give an account of mammalian genome imprinting.

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