The 42nd International Congress for the History of Pharmacy 8-11 Sep. 2015 ISTANBUL
P-01 Medicinal wines of Eastern and Western Hemisphere. Part 1: Some History Zbigniew Bela Museum of Pharmacy at the Jagiellonian University, Krakow, Poland
The above referenced subject has been executed in three parts, on the three consecutive posters. The first part (poster no. 16) is titled Some history, and shows examples of prescriptions for medicinal wines in the works of such authors as Hippocrates, Dioscorides, Galen, Avicenna, Arnald de Villanova, Quercetanus and Sydenham, as well as examples from pharmacopoeias and pharmaceutical textbooks from 17th to 20th century. The second part (poster no. 17) is called Medicinal wines dispensed by “Under the Golden Tiger” pharmacy in Krakow (Poland), while the third one (poster no. 18) shows a wall calendar entitled Apothecary medicinal wines, published by The Krakow Museum of Pharmacy.
P-02 Xysmalobium undulatum (Uzara) research– how everything began Axel Helmstaedter Institute of Pharmaceutical Chemistry, Goethe University, Frankfurt am Main, Germany
Xysmalobium undulatum (Uzara) is a traditionally used medicinal plant from South Africa. It found its way into European research in the early 20th century and has been widely used as a remedy against diarrhoea since then. Circumstances of knowledge transfer and early research into phytochemistry and therapeutic potential of X. undulatum have been largely unknown so far. As could be shown, the drug was brought to Europe by a former soldier, Wilhelm Heinrich Adolph Hopf (1887-1929). At the age of 16, W. H. A. Hopf joined the German navy, but some years later he moved to South Africa, where he was engaged in the Boer War. He married Mary Annie Langham Thomson (1876-1967) December 16, 1906. Most probably in 1909, the family returned to Melsungen (along with the Uzara roots) and stayed until the end of World War I. Then, Hopf and his wife moved to
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The 42nd International Congress for the History of Pharmacy 8-11 Sep. 2015 ISTANBUL
England, lived in Rugby and changed their name from Hopf to Hopford on 19 November 1918. They had two children. He died December 27, 1929 in Rugby. Details about Hopf’s life are provided here the first time, as well as some aspects of early research on the drug, which has mainly been done at the University of Marburg, Germany.
P-03 Pharmaceutical innovation in the early 20th Century - Salvarsan and its derivatives Susanne Odenweller, Axel Helmstädter Institute of Pharmaceutical Chemistry, Goethe Universität Frankfurt, Germany
Arsphenamine (Salvarsan), developed by Paul Ehrlich and launched in 1910 on the German market, was the first drug with significant effect against the syphilitic disease. It was the first drug of the so called `arsenophenamines´ and the breakthrough innovation in this class. It was, however, not easy in handling, showed several side effects and faced severe criticism in public. This is why Paul Ehrlich and the Hoechster Farben AG continued to develop additional compounds of the same class. Between 1912 and 1931 nine derivatives reached the market: - Neosalvarsan (Neoarsphenamine, 1912) - Kupfer-Salvarsan (Copper Arsphenamine, 1914) - Salvarsan-Natrium (Arspenamine Sodium, 1915) - Sulfoxylsalvarsan (1919) - Silbersalvarsan (Silver Arsphenamine, 1920) - Neosilbersalvarsan (Neosilver Arsphenamine, 1920/21) - Myosalvarsan (Sulpharsphenamine, 1926) - Solusalvarsan (1931) - Isosalvarsan As a first step in a research project about pharmaceutical innovation in the 20th century, it was investigated which Salvarsan derivative, and why, eventually earned greatest success. As could be shown, Neoarsphenamine was the most successful compound preparation with a market share of 94% between 1927 and 1942, although being neither the most potent nor the easiest to handle derivative in retrospective. It represented the first major improvement after Salvarsan had prepared the ground for chemotherapy of syphilis.
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