!   "#$   %& '   ((  )     *+ "#$    ',   *+ " - ( (( % ! (       - (      ,    $      $(  *$#   .  

                                                       ! " #    $           %

    &   %             '         (   )* + !  , ! ! ) !--*     '          

      (                  '       .                       -                   ! "                 /  0 $  ! "$   $  $ %  

 

  !!   "    " !! !!#  "$$  %!   "!    ! !$$# ! !$$ ! "!   " % & % $$ !    $ ' " ! $  ()*+  ,  " -  $ !$    ' "$! ( +# .!  ! !$$ "$ $ ) (  "+ "$ ! !' %! $ !  & % '  ! $  "$  $    " ! $! /!$ $/$  *0. !!# 1 ' $ $ $ " $   $$ $ ""$ & " &!  $ !!% &  $    " 2 $ !$'  % $ !  $    ' !  3  !! $$ $ -"!!  $ ) "$  ! ! $!  $ "$   !  % ! !  !' 3 "$ ! (45!+ (/    0 + $  ""$!! ( +  !&$!! 

'$ (. +#

1$!   $  *0. " $ !  ! % "$ (1  , +# 1 $$  %$  $ ) "$ & ! $  $  $"$'!!$  "$&"!  %$ ' " & (' +#   - $    $ ) "$ !   $$ % "$  .*'4#  $ "$   "& $  &!!  $ !$$  $  $ ) "$  !-$  !6!  .*'4 "% ! %&  ,! 1!$$$ (,17 # 2 +  $ %' $! (3/+    !6!   $ %!  $#$ "% !  ,%3#

                  

1            $/  $!$ $!% (8+  $ $ ! "!$ 9:';< (= 9+# !  .  !      8  ! "!  >;  ! "& ;?@  $ $$ !A  $ ) "$#  "$  0 2   ,# 5$# B # 4 # 9 0# > 8& >??;

9;9

     

8  ! !$ & &"%  $ $ %'     4 !!# "$$ ! $!  $ !$ "! (! 8$ !  8$' !+ "$ & !""$ $ -!$  $ 8    ! &  !!$$ "$!  $

 (!&+ !$$  $ 8  ' $  ' - $  $    &'&"% !%  $ ) "$ (= >+#

                 

        

          !    "#   $  %%  $

 & $  '(    )*

9;>

,# 5$# B # 4 # 9 0# > 8& >??;

+

 

C  "$  &!! ! 888 $ !$$ $$ $ 8   ! $ ) "$ $ $ !%!   ! ! $$ $ 0'$! ! "%% & $  $ -$  $ # C /! $ $$ $ 0'$! ! "!  ""-$ & $  !#  0'$! !  ! $  &   &' "  $   !% "1  ;#
  $  &  "1  E#F9 (%  9+#  "$ $!  &!! $ $  $ '  !! $$  "% !  ,3 (= ;'1

;'11  ;'111+# !  &!! !$$ $$ $ 8   %   $ ) "$   ' %!  $#$  !"$  $   &  $ "& !6!#   ! %!  $$ ! '  8 !     ! $$  $$ !  !!    $  8 #

                       ,- ./0

 

% " 

 " 

  

12*

()3

1*4

1*2



'' .')5/0

'( .('*/0

(* .2)*/0

)1 .2(1/0

6

25 .12'/0

'1 .(((/0

1' .(12/0

41 .(71/0



'4 .27'/0

7 .'1(/0

2( .'52/0

13 .2*(/0

,

'' .')5/0

5 .2'1/0

27 .2'7/0

17 .'55/0

 .0

75 .'**/0

12 .'**/0

'2* .'**/0

2(' .'**/0

&

4 .'*70

' .'(0

) .770

'1 .'410



1 .)(0

2 .270

4 .'*70

'1 .'410

 

( .(50

' .'(0

*

1 .)(0 1 .)(0

 

( .(50

*

' .'(0



2 .230

2 .270

' .'(0

) .770

 

' .'(0

' .'(0

' .'(0

( .(50



' .'(0

*

1 .)(0

) .770



' .'(0

2 .270

1 .)(0

3 .520

,

*

2 .270

' .'(0

( .(50



*

' .'(0

( .(50

1 .)(0

, 

*

' .'(0

' .'(0

2 .270



*

'.'(0

*

'.'(0



*

*

( .(50

( .(50

&

*

*

2 .270

2 .270

 

*

*

2 .270

2 .270

 

*

*

2 .270

2 .270



*

*

' .'(0

' .'(0



2( .(*(0

'1 .'410

(5 .)'(0

37 .'**0

   +  .0

215'

')37

1((*

4(7'



))2

(35

47'

7*'

%   

*

2

-2

*

.23/0

.23/8 -)1/0

.)1/8 -)1/0

,# 5$# B # 4 # 9 0# > 8& >??;

9;;

     

                                   

 $  !%  &!!  %!   !$ $  $ $ $ &!$!  $ $  $   $ ) "$# ! $ ! $ $ & $ $ 8   $ ) "$ 9;H

    

 $! $ &!$!  $   (0 ' ' &!'.' '&!'&!'0 'CC+# . !" !' $ (0 ' '&!',''&!'&!'G 'CC+ !  !   $ %-& '  $!  $  (!"3+ "$#  $ &!$! $$  "!$  %$ !$! &  $ ! / %! %' $ $ )   "$! "  $$ $&  

,# 5$# B # 4 # 9 0# > 8& >??;

+

 

$ """$ $$  $ !$$ ' $! !$!$ &"%$& (H<#H?@+   $ $!#  !$$ "$!#  ) "$  ! ! A $    $   ""$ (:#H?@  %$           "!$   $  !+ (%  9+# J! '  5  "$     !$   ! ""$

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
      

  ,  .08

  .0      .0       



,# 5$# B # 4 # 9 0# > 8& >??;

9;:

     

 $/  $$  $ "!$  $ ) "$ M ( !6+# ! $$ ' ! %&  %! "  $ "!   !6 JJ... $$ ! $  $ %'    $ M!#

 ,'   $ "$ 8   %$ $  $ ! !%  $ ) "' $# .! !  = H'1  %  > $ "' $  ! %& $ 8  ! $!   ,' !$  $ ) "$#

  ! "  # $   % &       

##

8 

) "$

. 

; (H#??@+

H (:#;;@+

&!

?

; (H#??@+

.!"

?

9 (9#;;@+

, 

?

; (H#??@+

5

; (H#??@+

H (:#;;@+

, &

?

> (>#F<@+

!

?

?

1 

9 (9#;;@+

; (H#??@+

&!

?

> (>#F<@+



E (9?#F<@+

9H (9E#F<@+

8$ .!

? 9 (9#;;@+

9 (9#;;@+ : (F#F<@+

9;F

 ,. , ,, ,J J, J,J ,. ,.J ,.. ,., JJ JJJ ,,. ,, ,,, ,,J . .J .J. .J .JJ ... .., J. J J, JJ JJ. JJ, .J, .. ..J

8  ? 9 (9#;;@+ 9 (9#;;@+ 9 (9#;;@+ ? ? ? ? ? ? > (>#F<@+ 9 (9#;;@+ ? ? ? ? ? ? ? 9 (9#;;@+ ? ? ? > (>#F<@+ ? ? : (F#F<@+ ? 9 (9#;;@+ ? ? 9 (9#;;@+

,# 5$# B # 4 # 9 0# > 8& >??;

) "$ ? 9 (9#;;@+ > (>#F<@+ 9 (9#;;@+ > (>#F<@+ 9 (9#;;@+ ? 9 (9#;;@+ ; (H#??@+ ? ; (H#??@+ 9 (9#;;@+ 9 (9#;;@+ ? ? 9 (9#;;@+ ? ? 9 (9#;;@+ 9 (9#;;@+ 9 (9#;;@+ > (>#F<@+ ? > (>#F<@+ ? > (>#F<@+ F (E#??@+ > (>#F<@+ > (>#F<@+ 9 (9#;;@+ > (>#F<@+ ; (H#??@+

+

 

  '   (

5

?

> (>#F<@+

, 

?

?

.

?

> (>#F<@+



9 (9#;;@+

< (D#;;@+



> (>#F<@+

: (F#F<@+

4

H (:#;;@+

9H (9E#F<@+

" &

? ?

? H (:#;;@+

C5

?

9 (9#;;@+

  

    

)  $ "$!  $ !$ !$&   !$ !!   $    !6!   $ $$ & ! $& %$ $ ) "$  & 3 !6!  ,3 $ $ $ !-$ $ & "% ! ! $!  .*'4# 1  "$   &!!  $ ) "$  .*'4  $ %!  $#$   $ %!  &   !  (='

.  , J .. ., .,. .,, ,. , ,, ,J ., .,J J. J J, JJ .. . ., .J ,J. ,J ,J, ,JJ J,, J. J.J J.. J., J,.

? ? ? ? ? ? ? ? ? ? ? ? 9 (9#;;@+ ? ? ? ? ? 9 (9#;;@+ ? ? 9 (9#;;@+ > (>#F<@+ 9 (9#;;@+ 9 (9#;;@+ ? ? ? ? ? ? ?

9 (9#;;@+ ? ? 9 (9#;;@+ ? ? ? ? 9 (9#;;@+ ? ? 9 (9#;;@+ 9 (9#;;@+ 9 (9#;;@+ 9 (9#;;@+ ? > (>#F<@+ > (>#F<@+ > (>#F<@+ ? > (>#F<@+ 9 (9#;;@+ ; (H#??@+ ; (H#??@+ > (>#F<@+ F (E#??@+ ? H (:#;;@+ ? 9 (9#;;@+ ? ?

 :+# $  $   !6 ! $&

$ .*'4 ) "$ ! $ !$ ! $& $ ,4 ($!!!%  !$$$! !7 H?2E>

HE#E@+  $ !$ $ .14 (  $! %$! !7 ;H29?D ;9#>@7 = F+# ! /!  !!$$ $ $ "& $ $ $$  ""! %!  $   !6  $ ) "$ (= <'1  <'11+# 0 $ ! &$ %   $ "% ! !6!# 5 !  &!!   " !!$ $$ $ ) "$ ! !$ 3 & $ %  '

,# 5$# B # 4 # 9 0# > 8& >??;

9;<

     

%  $  '$A 0; ) ) "$ ($$"K22#!##32$252!#!$ +

 & ( +  !   &  ! ' %!  $ !%  ! $& $$ !  %' !$$ "$!  !    ! $ $ ($$&L>92
 ) 

 "  "   9         !       

:#      

  $ :#    $  #    $ ;#     $ 225# "    225$ <1(# "    <1($ # "    $ =#   "    $ #   "     "   $ #    $ #  >   $ ,#  "      

 *  ! "   !  

          "        

"   ! 

     :?*' .# 225$ <# <1(0

9;E

,# 5$# B # 4 # 9 0# > 8& >??;

+

 

 + 

                 "   9         

  +  !

,# 5$# B # 4 # 9 0# > 8& >??;

9;D

     

  

J!$ $ "$!!  .*  $ ""$!  .*'4 !  $ !/  "%   $# .  !$" $ $!  ! $ ' !  3   $  "$! !$' $   & $!  $    "

  $ ) "$  ! $! # 1 ' $  $ !  %$ $  $' !"  $ ) "$ $ $ 8 "$  $ !$'   %  $ 0 "$ ( "$+  $  "!#   ! !  & !$ $ %  !'   "! "!  *0.  $ 0 "$  "" %&  !$'  " % & % $$ !  "  $    8 "' $! ""!  ! $ 0 "$ ( '   +# C ! $! !$$ $$ $ ) "$ ! $ ' "$ "$  $ !$'  %  !  "$$ !$$ 3 $ $  "$ $ "$ ! / %!#   

          

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

   $ M!# ! $$  $ ! " ! & "$ %& ! (JJ.. $ '>?? $ "' !$  $ ) "$ M7 # 2 +  $! (J.,.. $ '> $ "!$  $ !$$ 7 #  +# ! $$  $ !  ! $ $   !6#   5 ! -"$  '  !!$ $$  "$ $$ "!% & $ $ $!  ! $ $! $ Æ&  *0. $!"$!  $ ) "$ ( +#     $  !6  $ ) "$  $! $!"$  $ !$ $! $ -"' $ "#  & "$  !& !$$ !  !  "$$ "$  %$! $' $  $ 8 # C ! $! !!$$ & !$$ $ "!   '  ' $  $ "!$ $ 8 #   & I! &  %& ! %$! "!  $ %& $$!   "$%   '  "$  &!!#  '  $ /$!  $ &" 11 8  (0 +# ! $$$ ! % " $ "!!%  !' $3! %& $ "$ !$#  " ! & %' !  !   &!!  "  $ 8 "$ (! $ $  %$ $ 8 "$  $! !!+#  $   $ I$ !$ "! $ ! $  $$   !      $ $$  $ "$ 8 # C ! $! ! $$ $!  $3! " # 1  $    $ A $ "!!%  "$ ! $ !$$!  "$K /!$

 ""  I$  &!! !$ $ I$ $ $!  "$! $ $  &!!  $ .*'4 ) "$ (## 8  -K 99';: "' $ %& $" 8  -  $! $ !K 9<';H "$ %& "+7 ! &  ! $ ! !$ " ! & !  $  &!!  $ ) "$  $ 3 %!  $#$ (= ;+ # MI$  &$ $!   $ I &   $$ $ 8  !  $$ $ %& I!  %& $$ "!!%  ' $$  %& !   $ "$!  $ "&! 2  $!# !  ! !  $ "$  &!! "!  ! $  $"$$   ! $!# =$'   &!!  $ ) "$   $ $ ' %!  $#$  ! !""$ $ -!$  $ 8 # . -$ 8  ! % $$    %!  ," 11 %$ $ -!$  !  ! 8   $ .*'4 ) "$ !

,# 5$# B # 4 # 9 0# > 8& >??;

+

 

% / & - #  ""! $$ $ $$  $ "$ 8    % $ 0'$!  $ -$  $ # 1$ ! !!$$ $ $ $ " ! & "$  84  ,4 ('  0 +  $   ' &!! ! $  $ 8 "$ (! $ $  %$ $ 8 "$  $! !!+#  '$! ! "!$ $ $ %  $ $  $ #  "!  "!' $ $  &!& $ !$!  $ '$   $ ) "$ !  % $# ! " !  ! %!   4'>>D)  *4  ! $ ! $" & $ $ ) "$  .*'4    % !""$ %& -"$  %' $  #  $$ !  $ $ !$  $ !$$ $ $  $ ) "$  $!  '   $ $  "$! !  ! $   "$  $ $ !#  $ ! !!& $ "!A  $$ $!  ! !  ! $! ""!  $! !$& !  %  !  3  %!  %$!  &!!  $ !6 $  % $"$  $ $ "!"' $ # 1$  % $!$ "$  ! $    ! $   $ !$$ &   $#   ! !  $ % / A $ $ -"$ $  !""$ #      

   

   

 ) "$ ! "!$ $ $   $ !$$ 3 $ $  "$ $ $ "$ ! ' / %!   $ $ -"$ $ $ / "    & $ $3 %$ $  !$$  $   %!  $ $' $  $! "$! !  ! $!  $!" $ !$  !#   "$ ! $ !$ !$$ "$   !!  ! %  ! $  "$ !"!%    $$$  $& $ $ !$  (1 + $$& !$   $!! $"!    "$!!  ' $ $ $ !$$$  $ $!$ !"3!  $ !  $  (,3/+#   "$ ! "!' $ $ $ "$ $ $    " $ $! 8   $ $ !$'  %# 1$  ! $$! $ $ 8 "$  $  !  $ !  $ !$ ! ! (/ +# . $ $A %& $ &!$! (0 '

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

,# 5$# B # 4 # 9 0# > 8& >??;

9H9

     

 ,     

@  !         

 $  $ '  $'" & $$   "$!   % "$$ $ $ $!  $$  $ !#  %'  !/  $! ! & ! $ !$$ $ /!$ !$$ 3 %$ $ $  !$' $ "$!  .*'4# C $ ! / $ $  " $ $"$$  $ $' $ %$ $ !  $! !$ "!!%  ! $!$ "$&!  $   $  $ $ "$!  "$!!  $$&#

  % !"!%    $ $ "!!%  ' $!  $ ) "$# 1$ ! % "$ $$ $ $$! $ $ $ '$   $ ) "$  84 &  $ %  !! (' +#  "$ ! ""$! $ $ 0'$   $ ) "$ $  !$ 3 &    !$ (. '0+ $ ! "!$ H;'HH   % $  $   %  ! %& $   ' !     !#  !""$   '  !  $! "!  $ ) "$  !  $" &  $  !!# $ $ ) "$  !  "         84 !  $ $$  % $$

        $      ! ""$ (/ +# 5' )   $! %& $ ) "$  %&  $! $  $ &   & "$   %& $$!  $ ) ! $  $ ) "$#  %& "$ $ $ !$$  "' $! ! %  $ (' +# )  $  -' #    

 $   "!!   !  $  (/  ' + $ -"!!       $ ) "$  $ " ! & 3 '  !! ! % "$ $ %     " ' C  $ ! ! %& !6  &!! ! $$ $ $ (1  , + ""$!! ( + !&$!!  '$ ) "$   !! ! ! 6 $$ $ ! ' (. + $  $"$'!!$  "$&"!  $  & $ 3 !6!   $ %$ " & (' +  ""! & $ ) "$  $   " ( %+ !! $! !$$ $$ $ ) "$ !   ' $ $ $#$# $$ "$ ( +# )  & &"$!!   % ""! $ 1 !  $! $!  $ ) "$   %   $ .*'4 !  &!$&# 1 $  $ %& $ !$ (""-$ & 9H !!+   $  3  $$ $$ 6& ! "' 0'$   $ -$  $ ;D'! "$ $   $ $  $3 $     '$   $ $  $  ! $3  !  &!   !$ ) "$ $ $ 8  $!  %$  $  $ )    $ $! $&" "$$ $ ! $ "!! "$ (>;2

,# 5$# B # 4 # 9 0# > 8& >??;

+

 

$ "!$  (!$  $!! $"! " $ $ $#+  $  (" $ !  $ %$ $ $  $ $&  !$! $#+# !  $ !6 $ !" & $ 6' !!  $ ) "$  "!$ $ $$ $ ) "' $     %    "$ &  & $  "$!   !!    '  !$# 1$   $ % $ %& ' $  "$ $$   !$ $ %&  !     %$  $! $ "$!  & $  !  %& !O (!' $2 $  !$ " $+  !' % &  !$! %& $ A$ $!# 1$     % -!$   '     $ "%% & $$  $$ $ ! $ $! $ $$  !$% !   3 $ !#      !""$  &"$!!# =!$ &  $%& !$ $ ! ! % ' $$     ! !!$ $$ $ $ $ %  $$ !  !(99+#  &

$ !/$ ! $&  $! !& !$$  $ !  $ !$$   ) "' $!   !!  !"$  $    $ "& !$$ !!$ $$ $ ! -"'  $ ! $  $    $#  &

 $  &  $!  $$ %& "' !   $ "% ! !6!  .*'4# 0 !6 $ ! &$ % "$# )  $ !A  $ ) "$ !  & ""-$ & ?#>@ (>>E2>D<>:+  $  $  $  $ ) "$ !$   $ % !$!$ & $"$ %& !"  !A $ %!  $  $$ $ "$# 1 $  !! $ ) "$ !  &! %  $ % $   ! $&"!  $$   % $$  $ ! (' +#   $  !$% $&  $ ) "$    $  " $  $ !$ $!!!    $!    $! "$$ $ %!! $!   $& !/# .! $ ! !$ 3 !$$ "$  $ $& .*'4  $ ) "$  ! $ %!$ &!$& $ -" #

           

!6 ! 8.)9??? (.! 0 !& J.+# !   $$    !!% &  " %& 5 !!8$  5" ($$"K22#""#+ !"$  &#  !6!  $ $ " $   $ ! !!%  %& ,1   % "!$  ,3 (!! %!K . >
. >DE#9+    %   &# . $ -"$ $ !

  $ M0.  ! "!$ ! !' $!  $   $ 3 !6!

   %    %$! (! "" $& M$%!K $$"K22#!##2.*2+# % $      

 !   !$ !$  "% !  "!  $! !$&# N& $! "!   C*= = ($$"K22#%# ## 22#$ + $ ' $ C*= M0. ,   $ ($$"K22# #!$$#2$"2!2M0. 2+ $ ' &A $ , $$  $ )8C " ($$"K22#"###32$2)8C2 .""!2+  .$"$ :#? ($$"K22$"$' "% #%"#2+  "&!  % $! "$# = 8  "$  ! 888 ($$"K22#%#$#32! !28882+

"5> ($$"K22%%#"!$#2!6 2"$2 $'3#$ + 8" ($$"K22##%$# 2!$285*)M #$ +  $" ($$"K22%!##32$!2$ 2;?>>E99# $ + ! $! &  "$   ' &!!  "$ "$$ /' $#  "!  ! $  !& !$$ "$K 51" ($$"K22%#!# ##32"!"2+

00"$ ($$"K22#"#!#22"$# $ + 51 ($$"K22 #!#2!" $2+  .$"$ :#?# .!  $ "& $  ' &!!  !  !$  ($$"K22'%#' !$!%#212 !$ +  $"  !' 6  $ !  ! 5=.8 ! ($$"K22#!##32$252!# !$ +  "$  &  !!/$#

 ! 

 "!   $ .*'4 !" !  "$$!  "" *0.  !6  $3 8!$&     &    % !% " ! & (2 +#  "  ! .&  !  0$ ,# 5$# B # 4 # 9 0# > 8& >??;

9H;

     

0$  =$    / !"' "$#   ! $ $ -"!!  $3 !! $  ' %$!   !  53 J 8   !"$ 0$ $  M!! $    $ 8" , $!    A#

   

  "  8 %! B >8

6 2  8   

"  2***     

            ,  " C          >   

  

31#

1('51(27 '555      " 

         "           

  

3(#

34)(34)5

 

1 8 ?8

2**' "      

     ) :  C8 8

 

 

24'# '7('75

'554       

 " !  "                   > 

  

32#

47(4471( 7 < 8 ?8

 

2**2 ,      

"8  @       

 

"

 " 

  

  

  

37# '')'4'')25

3 A 8 &   8  2**2 ,           !    C  "    ""         " 

   37# 15431555   '554    

 

 "   "     @ "              " 

 



 

2**(  "  9    "

          . 

      14# 51'514 8   2**(     E

  

     !       

9HH

 

'2  8 B8

 " 9   

 

(**# '(55

2**(

"    

" 9      '1        "" "    !  



   

(7'# '335'34)

'1   8 68

 

2*** = "  

        ""   

   ') ,8 8



(14#'514'5)'



23)# 25*''25*22

 

'552

,     <;1

   ""             

 

'44# 77773)

 

'7 :  8 &8

'553

! "  

    % "    "         >             " '3 

E8 8

   

223# (34(44

'555    "

"      >    "            "    

 "     '4 & ,F 8 8

  

 

3(# 37*337'4

'554    "

 !    >   "     " 

  )5#  "

  

D)5    "   32# 572457(7

'5 ,   8   :

" 8 ? 2**'

 

  >          

 

235# (3'(31

  '554         

2* , F8 8

 

'55)

 "     72# ''3'''5*   E   

 "  "     " "  "      "  



  

7# '(')'((2

 

'554       

" #  "     9  "    ""    

  

2( ""8 ?:8

:?*'0 '* 8

2**(

'1*1

22  8 8

32# 344)3451

5 D8 =8

 

      

2' & > 8 ?A8

   4 ;

 8 ;8

''  8 8

(**# '(51'(55

    

    

 

 

'(  "8 A 2**(     

'  8 =  : !8 =A .0 '55*

( 8 8

 "

32# 74(474)*

 

2***     E 

     "       )5 " ""    

  

,# 5$# B # 4 # 9 0# > 8& >??;

31# 2(((2(12

The E Protein Is a Multifunctional Membrane Protein of ...

of three software programs (see Materials and Meth- ... Software programs: I. PSIpred; II. NNPrediCt;. III. ..... genome.iastate.edu/ftp/share/DNAgcCal/) to ana-.
Download PDF
337KB Sizes 1 Downloads 181 Views
Report

Recommend Documents

The mdoC Gene of Escherichia coli Encodes a Membrane Protein ...
the second class contains the very similar genes of Escherichia coli (mdoG and .... containing the putative coding region of mdoC (see Fig. 3) was purified and ... using computer programs made available from Infobiogen (15a). Thin-layer ..... Sanger
Silencing of latent membrane protein 2B reduces ...
at the indicated times before and after BCR cross-linking with a specific Taqman system. The mRNA .... like Southern–PCR (Tao et al., 1998) or qRT-PCR, as.
Extracting Protein-Protein Interactions from ... - Semantic Scholar
statistical methods for mining knowledge from texts and biomedical data mining. ..... the Internet with the keyword “protein-protein interaction”. Corpuses I and II ...
The arbuscular mycorrhizal fungal protein glomalin is a ...
Aug 9, 2006 - Operationally defined and extracted from soil as glomalin- related soil protein (GRSP; ... A duplicate SDS-PAGE gel was prepared and stained ...
Extracting Protein-Protein Interactions from ... - Semantic Scholar
Existing statistical approaches to this problem include sliding-window methods (Bakiri and Dietterich, 2002), hidden Markov models (Rabiner, 1989), maximum ..... MAP estimation methods investigated in speech recognition experiments (Iyer et al.,. 199
Latent Membrane Protein 2B Regulates Susceptibility ...
cipitation (IP) kit according to the manufacturer's instructions. IPs were per- formed with the ... done with Prism 4 (GraphPad Software, Inc.). Calcium mobilization.
Insulin Receptor Substrate protein 53 kDa (IRSp53) is a negative ...
Insulin Receptor Substrate protein 53 kDa (IRSp53) is a negative regulator of myogenic differentiation.pdf. Insulin Receptor Substrate protein 53 kDa (IRSp53) is ...
Validating Text Mining Results on Protein-Protein ...
a few big known protein complexes that have clearly defined interactions ... comparison to random pairs, while in the other three species only slightly ... ing results from gene expression data has been proposed. Since .... Term Database.
Extracting Protein-Protein interactions using simple ...
datasets and the limited information available about their methods. 2 Data. A gene-interaction .... from text–is text mining ready to deliver? PLoS Biol, 3(2).
The multidomain protein Brpf1 binds histones and is ... - CiteSeerX
This is the first demonstration of histone binding for PWWP domains. Mutant analyses further show that the PWWP domain is absolutely essential for Brpf1 ...
Extracting Protein-Protein interactions using simple ...
using 10-fold cross-validation. Performance will be measured using Recall, Precision and F1. 3 Experiments. Each possible combination of proteins and iWords.
Extracting Protein-Protein interactions using simple ...
References. C. Blaschke and A. Valencia. 2002. The frame-based module of the suiseki information extraction system. IEEE Intelli- gent Systems, (17):14–20.
Effective Reranking for Extracting Protein-Protein ... - Semantic Scholar
School of Computer Engineering, Nanyang Technological University, ... of extracting important fields from the headers of computer science research papers. .... reranking, the top ranked parse is processed to extract protein-protein interactions.
The multidomain protein Brpf1 binds histones and is ... - CiteSeerX
KEY WORDS: Brpf1, Bromodomain, PWWP domain, Moz, Hox gene expression, Craniofacial development, Cranial neural crest, .... in buffer I (50 mM Tris-HCl pH 8, 150 mM NaCl, 0.75% Triton X-100, ...... A two-color acid-free cartilage and.
Effective Reranking for Extracting Protein-Protein ... - Semantic Scholar
School of Computer Engineering, Nanyang Technological University, ... different models, log-linear regression (LLR), neural networks (NNs) and support vector .... reranking, the top ranked parse is processed to extract protein-protein ...