(BPH 40112) B.Pharmacy DEGREE

I~XAMINATlON, ArHIL

:3.

(a)

20] G.

Or

(Supplementary)

(b)

Fourth Semester Paper I ­ PHARMACEUTICAL CHEMISTRY-lIl (MEDICINAL ­ I)

1.

What do you know of (i)

Anthelrncntics

(ii)

Anti-arnoebics.

Outline the synthesis and uses of (a)

(Regulation 2012-201:3) Time: Three hours

Classify Antimalariala, discuss their SAR, therapeutic uses and write the synthesis of pyrimethamine.

Maximum: 70 marks

(i)

Iproniazid

(ii)

Clotrimazole

(iii)

Dapsone.

Answer ALL questions. l.

(a),

Or

Explain with suitable examples the importance of partition coefficient in relation to Biological activity of drugs.

(b)

Or (b)

2.

(a)

How do you classify sulfonamides and discuss the mode of action and uses. Outline the synthesis of sulfamethoxazole and Trimethoprim. Give an account of penicillins with emphasis on therapeutic uses and their stability. Or

(b)

Write a short notes on (i)

Tetracyclines

(ii)

Macrolides.

5.

(a)

(i)

Ketoconazole

(ii)

Ethambutol

(iii)

Clofazimine.

Give an account of HIV-Protease inhibitors and write the synthesis of Idoxurudine. Or

(b)

Write briefly on (i)

Anti metabolites

(ii)

Vinca alkaloids

2

(BPH 40112)

(BPH 40212)

B.Pharmacy

])I~GREE

EXAMINATION, APRIL 2016.

(Supplementary)

Fourth Semester

Paper II - PHYSICAL PHARMACY - II

(Regulation 2012-2013)

Time: Three hours

Maximum: 70 marks

Answer ALL questions.

Each question carries 14 marks.

1.

(a)

State and explain Henry's law. What are its applications? (7)

(b)

Write about Fick's first and second laws of diffusion. (7) Or

2.

(a)

Write about inclusion complexes and their pharmaceutical applications. (8)

(b)

Write about protein binding implications on drug action.

and

its (6)

:3.

(a)

(b)

Explnin the principle of accelerated stability testing and how the shelf life of ,\ product is determined using temperature as stt'ess condftion. (l0) The initial concentration of drug in a solution was found to be' 500 units/rn L. It was found to contain 300 units/mi. after 40 days following first order decomposition. Calculate the time required for decomposing the initial concentration to 250 units/mL. (4)

fl.

7.

5.

Derive the expression for calculation of first order reaction rate constant and half life. (6)

(b)

What arc the methods available ascertaining the order of reaction?

(c)

A. solution of glucose in aqueous solution with a concentration of 0.056 Moles/liter found to follow first order decomposition. The concentration after a period of 12 hours was found to 1.10 x 10-~ Moles/liter. Estimate the amount of glucose lost during the period of 24 hours. (4)

for (4)

Spreading coefficient

(5)

(b)

Surface active agents

(5)

(c)

Contact angle

(4)

Bl~T

(b)

Write about

(a)

What arc colloids? Give their classification and compare the properties of lyophilic and lyophobic colloids. (8)

(b)

Write: about sedimentation parameter's.

adsorption isotherm.

(7)

(6)

(a)

Write about theories of emulsification.

(b)

Wr it« about derived properties of powders and their significance in dosage from design.

(7)

(7) D.

(a)

Define Newton's law of flow and explain its application in differentiating Newtonian and non-Newtonian systems. (G)

(b)

Write about the significance of rheology in pharmacy and explain the applications of non-Newtonian systems with suitable examples. (8)

Or 10.

(a)

I~xplain the working of cup and bob viscometer and mention its advantages and disadvantages in comparison with other rotational viscomcters. (9)

(b)

Write about Bingham bodies.

Write about the following: (a)

(7)

Or H

(a)

I';xplain the concepts of electrical double layer.

Or 1.

(a)

(5)

Or 2

(BPH 40212)

:3

(BPH 40212)

(BPH 40412) B.PHARMACY DEGREE EXAMINATION,

APRIL 2016.

(Supplementary)

Fourth Semester

Paper III - APPLIED BIOCHEMISTRY AND

CLINICAL PATHOLOGY

(Regulation 2012 - 13)

Maximum: 70 marks

Time : Three hours

Answer ALL questions. 1.

(a)

Classify lipids with examples? What is their significance in cell membrane biochemistry? Add a note on betaoxidation of lipids. Or

2.

(b)

With, a neat sketch phosphorylation cycle.

(a)

Explain the biosynthesis of cholesterol. Write in brief on the significance of cholesterol in health and disease. Or

(b)

Write in brief on : (i)

Glycogenesis

(ii)

Ketogenesis.

explain

oxidative

3.

(a)

5.

Write short notes on : (i)

Essential amino acids

(ii)

Metabolism of tyrosine and glycine.

(a)

Write the principle, procedure significance of the following tests (i)

SGOT

(ii)

Blood glucose

(iii)

Cholesterol.

and

Or Or (b)

4.

(a)

Write in brief on :

(b)

(i)

Deamination reactions in amino acid metabolism

(ii)

Metabolism tryptophan.

of

phenylalanine

Write a detailed significance of

note

pathological

(i)

lymphocytes and platelets

(ii)

bile salts.

and

Classify enzymes with examples. What is an enzyme inhibitor what is its role in health and disease?

Or (b)

Write in detail on the following as coenzymes (i)

NADH

(ii)

ATP

(iii)

Acetyl-CoA

(iv)

Folic acid. 2

(BPH 40412)

3

(BPH 40412)

(BPH 40612)

(b)

Explain about the genera] labelling requirements as per the Drugs and Cosmetics Act 1940. What are the special labelling requirements with respect to schedule G, schedule H and schedule X.

(a)

Define advertisement and magic remedy as per the Drugs and Magic Remedies Act. What are the prohibited advertisements as per this Act?

B.l'harmacy DEGRl'~I~ EXAMINATION, APRIL 20]6. Fourth Semester

3.

(Supplementary) Paper IV ­

FORENSIC PHARMACY

Or

(Regulation 2012-13) Time: Three hours

Maximum: 70 marks

(b)

Define denatured spirit, rectified spirit and absolute alcohol. Write a note on manufacture in bond.

(a)

Write a detailed note on the Poisons Act.

Answer ALL the questions.

All questions carry equal marks. 1.

(a)

1.

Or

Explain the state of affairs in India, with respect to medicines, in the 1930s. What were the recommendations of the Drugs I~nquiry Committee?

(b)

Explain the offences and the corresponding penalties, with respect to opium, cocaine and cannabis, under the Narcotics and Psychotropic Substances Act.

(a)

Explain the procedure for getting a patent in India.

Or (b)

2.

(a)

Explain how the Pharmacy Council of India is constituted. Write a note on Education Regulations 1991. Explain about the manufacture of drugs specified in Schedules C, C. and X.

G.

Or (b)

Write a summary of the Medical Termination of Pregnancy Act.

Or 2

(BPH 40612)