Childhood leukemia around French nuclear power plants—The geocap...

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http://onlinelibrary.wiley.com/doi/10.1002/ijc.27425/abstract

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Childhood leukemia around French nuclear power plants—The geocap study, 2002–2007 1. Claire Sermage-Faure1,2, 2. Dominique Laurier4, 3. Stéphanie Goujon-Bellec1,2,3, 4. Michel Chartier5, 5. Aurélie Guyot-Goubin1,2,3, 6. Jérémie Rudant1,2,3, 7. Denis Hémon1,2, 8. Jacqueline Clavel1,2,3,†,* Article first published online: 28 FEB 2012 DOI: 10.1002/ijc.27425 Copyright © 2012 UICC Issue

International Journal of Cancer Volume 131, Issue 5, (/doi/10.1002/ijc.v131.5/issuetoc) pages E769–E780, 1 September 2012 Additional Information How to Cite Sermage-Faure, C., Laurier, D., Goujon-Bellec, S., Chartier, M., Guyot-Goubin, A., Rudant, J., Hémon, D. and Clavel, J. (2012), Childhood leukemia around French nuclear power plants—The geocap study, 2002–2007. Int. J. Cancer, 131: E769–E780. doi: 10.1002/ijc.27425 10/17/2012 4:20 AM

Childhood leukemia around French nuclear power plants—The geocap...

2 of 4

http://onlinelibrary.wiley.com/doi/10.1002/ijc.27425/abstract

Author Information 1

INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France 2

Université Paris-Sud, UMRS1018, F-94807, Villejuif, Paris, France

3

French National Registry of Childhood Hematological malignancies (NRCH), Villejuif F-94807, Paris, France 4

Institute of Radiological Protection and Nuclear Safety, IRSN/DRPH/SRBE, Fontenayaux-Roses F-92262, Cedex, France 5

Institute of Radiological Protection and Nuclear Safety, IRSN/DRPH/SER, F-92262, Fontenayaux-Roses, France †

Tel.: +33-1-45-59-5037, Fax: +33-1-45-59-5151

Email: Jacqueline Clavel ([email protected]) *

CESP Equipe 6, INSERM U1018, 16 av. Paul Vaillant-Couturier, F-94807 Villejuif, Cedex, France

Publication History 1. 2. 3. 4. 5.

Issue published online: 27 JUN 2012 Article first published online: 28 FEB 2012 Accepted manuscript online: 5 JAN 2012 05:36AM EST Manuscript Accepted: 20 DEC 2011 Manuscript Received: 24 AUG 2011

Funded by Institut de Veille Sanitaire (InVS) Agence Nationale de Sécurité Sanitaire de l'Alimentation de l'Environnement et du Travail (ANSES) Association pour la Recherche sur le Cancer (ARC) Fondation Pfizer, Institut National du Cancer (INCa) Agence Nationale de la Recherche (ANR) Abstract Article (/doi/10.1002/ijc.27425/full) References (/doi/10.1002/ijc.27425/references) Supporting Information (/doi/10.1002/ijc.27425/suppinfo) Cited By (/doi/10.1002/ijc.27425/citedby) View Full Article with Supporting Information (HTML) (/doi/10.1002/ijc.27425/full) Get PDF (190K) (/doi/10.1002/ijc.27425/pdf)

Keywords: childhood leukemia; epidemiology; incidence; case–control; nuclear reactors

10/17/2012 4:20 AM

Childhood leukemia around French nuclear power plants—The geocap...

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http://onlinelibrary.wiley.com/doi/10.1002/ijc.27425/abstract

Abstract The aim of this work is to study the risk of childhood acute leukemia (AL) around French nuclear power plants (NPPs). The nationwide Geocap case–control study included the 2,753 cases diagnosed in mainland France over 2002–2007 and 30,000 contemporaneous population controls. The last addresses were geocoded and located around the 19 NPPs. The study used distance to NPPs and a dose-based geographic zoning (DBGZ), based on the estimated dose to bone marrow related to NPP gaseous discharges. An odds ratio (OR) of 1.9 [1.0–3.3], based on 14 cases, was evidenced for children living within 5 km of NPPs compared to those living 20 km or further away, and a very similar association was observed in the concomitant incidence study (standardized incidence ratio (SIR) = 1.9 [1.0–3.2]). These results were similar for all the 5-year-age groups. They persisted after stratification for several contextual characteristics of the municipalities of residence. Conversely, using the DBGZ resulted in OR and SIR close to one in all of the dose categories. There was no increase in AL incidence over 1990–2001 and over the entire 1990–2007 period. The results suggest a possible excess risk of AL in the close vicinity of French NPPs in 2002–2007. The absence of any association with the DBGZ may indicate that the association is not explained by NPP gaseous discharges. Overall, the findings call for investigation for potential risk factors related to the vicinity of NPP and collaborative analysis of multisite studies conducted in various countries. View Full Article with Supporting Information (HTML) (/doi/10.1002/ijc.27425/full) Get PDF (190K) (/doi/10.1002/ijc.27425/pdf)

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