Curriculum Vitae Yen Ta Huang (黃彥達), M.D., M.S, Ph.D. Gender: male Date of birth: October 4, 1974 Place of birth: Taipei, Taiwan Nationality: Taiwan Current Positions:  Physician Scientist of Department of Surgery in Buddhist Tzu Chi General Hospital, Hualien, Taiwan. (January 2016~now)  Adjunct Associate Professor of Department of Pharmacology & Master Program/PhD Program in Pharmacology and Toxicology in Tzu Chi University, Hualien, Taiwan (February 2016~now)  Attending Physician of Surgical Intensive Care Unit in Buddhist Tzu Chi General Hospital, Hualien, Taiwan. (June 2009~now)  Consultant of Taiwan Drug Relief Foundation (May 2015~now) Contact Information:  Tel:+886-3-8561825 Ext. 17630  Address: Room 827 in Xie Li Building, 707, Sec.3, Chung Yang Rd., Hualien, 970, Taiwan  E-mail: [email protected]  blog: http://yentahuang.blogspot.tw  Line ID: uncledahuang Education:  Doctor of Medicine (September 1993 - June 2000): School of Medicine, National Taiwan University, Taipei, Taiwan  Master of Science (September 2004 - August 2006): Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan Thesis: Brain-derived Neurotrophic Factor Promotes Bladder Cancer Growth in SCID Mice  Doctor of Philosophy (September 2006 - January 2011): Institute of Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan Dissertation: Targeted TrkB Blockade for Transitional Cell Carcinoma Therapy Training and Experiences:

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Internship in National Taiwan University Hospital, Taipei, Taiwan (June 1999 June 2000) Residency in Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan (August 2000 - July 2003) Residency in Department of Emergency Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan (August 2003 - June 2005) Attending Physician in Department of Emergency Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan (July 2005 - May 2009) Attending Physician in Medical Intensive Care Unit, Buddhist Tzu Chi General Hospital, Hualien, Taiwan (October 2005 - August 2007) Attending Physician in Surgical Intensive Care Unit, Buddhist Tzu Chi General Hospital, Hualien, Taiwan (June 2009 - now) Assistant Professor in Department of Pharmacology, Tzu Chi University, Hualien, Taiwan (August 2011 - July 2014) Postdoctoral Fellowship in Department of Emergency & Critical Care Medicine, Nagoya University, Nagoya, Japan (November 2014 - May 2015)

Academic Appointment:  Assistant Professor in Department of Pharmacology, Tzu Chi University, Hualien, Taiwan (August 2011 - July 2014)  Adjunct Assistant Professor in School of Medicine, Tzu Chi University, Hualien, Taiwan (November 2014~January 2016)  Adjunct Associate Professor in Master Program/PhD Program in Pharmacology and Toxicology, College of Medicine, Tzu Chi University, Hualien, Taiwan (January 2016~now)

Board Certification:  Republic of China Board of Internal Medicine  Republic of China Board of Emergency Medicine 

Republic of China Board of Critical Care

Membership in Professional Societies:  Taiwan Society of Internal Medicine  Taiwan Society of Emergency Medicine  Taiwan Society of Critical Care Medicine  The Pharmacological Society in Taiwan

Honor / Awards:  Best resident (No.2), Buddhist Tzu Chi General Hospital (2001)  Excellent staff, Buddhist Tzu Chi General Hospital (2002)  Excellent journal award, Tzu Chi Medical Journal (2011)  Excellent teacher of attending physician, Buddhist Tzu Chi General Hospital (2011, 2012, 2013, 2014)  Excellent teacher of Tzu Chi University (2013)  Scholarship of 2014 Takeda Pharmaceuticals (2014)  Outstanding young people of Hualien city (2014) Publications: Journal Articles - (# co-author; *corresponding author) 2005 1. 黃彥達、胡勝川: 2004 年版 ACLS 之改變。台灣醫界雜誌 2005; 48(4), 30-34。 2. Chih Wei Hsu, Yen Ta Huang, Giou Teng Yiang, Hsing Cahng, Sheng Chuan Hu: Opinions about the Emergency Medical Services in Taiwan among Medical Personnel. J Taiwan Emerg Med. 2005; 7(2), 55-68. 3. Hsing Chang, Giou-Teng Yiang, Chih Wei Hsu, Yen Ta Huang, Sheng Chuan Hu: Public Perception regarding EMS in Taiwan. Tzu Chi Med J 2005; 17(3), 163-168. 2006 4. Kun Chuan Chen, Hsing Chang, Yen Ta Huang, Chih Wei Hsu, Giou Teng Yang, Sheng Chuan Hu: A survey of School Emergency Medical Services in Taiwan. J Taiwan Emerg Med. 2006; 8(2), 37-48. 5. Pei Chun Lai, Yen Ta Huang, Pen Jung Wang: A Seasonal Outbreak of Pediatric Aseptic Meningitis in East Taiwan: Clinical Presentations and Laboratory Analyses. Tzu Chi Med J. 2006; 18(6), 423-426. 2007 6. Yen Ta Huang, Pei Chun Lai, Chien Yu Su,Yi Ting Chen, Chuan Zhong Cai, and Chih Hsien Wang: Intermediate Syndrome after Organophosphate Ingestion: Case Report and Literature Review. Tzu Chi Med J. 2007; 19(3), 159-163. 7. Chi-Cheng Li, Ji Hung Wang, Yen Ta Huang, Han Yu Huang, Tso Fu Wang, Sung Chao Chu, Chao Yuan Yao, Yi Feng Wu, Szu Chin Li, Kuan Po Huang, Wei Han Huang, Ming Ching Shen, Ruey Ho Kao: Clinical Experiences with Recombinant Activated Factor VII for Managing Uncontrolled Hemorrhage in Non-Hemophilic Patients. Tzu Chi Med J. 2007; 19(4), 220-225.

2008 8. 黃彥達，賴佩君，胡勝川: 新版小兒高級救命術的改變與應注意之處。當代醫 學 2008; 35 (1), 48-54。 9. Yen Ta Huang, Chih Wei Hsu and Ted H. Chiu: Thalidomide and its Analogues as Anticancer Agents. Tzu Chi Med J. 2008; 20(3), 188-195. 2010 10. Yen Ta Huang, Pei Chun Lai, Chia Chen Wu, Shih Hsin Hsu, Chuan Chu Cheng, Yi Fan Lan and Ted H. Chiu: BDNF Mediated TrkB Activation is a Survival Signal for Transitional Cell Carcinoma Cells. Int J Oncol. 2010; 36(6), 1469-1476. (SCI, NSC-97-2314-B-303-016, IF 3.025, ranking 96/211=45.5% in Oncology) 11. Yen Ta Huang, Pei Chun Lai, Chia Chen Wu, Chuan Chu Cheng, and Ted H. Chiu: TrkB Antibody Elicits Cytotoxicity and Suppresses Migration/Invasion of Transitional Cell Carcinoma Cells. Int J Oncol. 2010; 37(4), 943-949. (SCI, NSC-97-2314-B-303-016, IF 3.025, ranking 96/211=45.5% in Oncology) 12. Pei Chun Lai, Ted H. Chiu*,#, and Yen Ta Huang*,#: Overexpression of BDNF and TrkB in Human Bladder Cancer Specimens. Oncol Rep. 2010; 24(5), 1265-1270. (SCI, NSC-97-2314-B-303-016, IF 2.301, ranking 138/211=65.4% in Oncology) 13. Pei Chun Lai, Te Chao Fang, Chuan Chu Cheng, Ted H. Chiu, and Yen Ta Huang*: Lestaurtinib is Cytotoxic to Oxaliplatin- resistant Transitional Cell Carcinoma Cell Line T24 In Vitro. Tzu Chi Med J. 2010 2010; 22(3), 125-130. 14. Pei Chun Lai, Te Chao Fang, Ted H. Chiu, and Yen Ta Huang*: Overexpression of Securin in Human Transitional Cell Carcinoma Specimens. Tzu Chi Med J. 2010; 22(4), 171-166. 2011 15. Ming Jen Tsai, Chin Piao Chen, Sung Ho Chen, Yen Ta Huang, and Ted H. Chiu: Pomalidomide Suppresses Cerulein-induced Acute Pancreatitis in Mice. J Gastroenterol. 2011; 46(6), 822-833. (SCI, IF 4.523, ranking 14/76=18.4% in Gastroenterology & Hepatology) 16. Pei Chun Lai, Yen Ta Huang, Chia Chen Wu, Ching Jung Lai, Pen Jung Wang, and Ted H. Chiu: Ceftriaxone Attenuates Hypoxic-Ischemic Brain Injury in Neonatal Rats. J Biomed Sci. 2011; 18(1), 69. (SCI, IF 2.763, ranking 50/123=40.7% in Research & Experimental Medicine) 2012 17. Pei Chun Lai, Shu Huey Chen, Shang Hsien Yang, Chuan Chu Cheng, Ted H.

Chiu, and Yen Ta Huang*: Novel Survivin Inhibitor YM155 Elicits Cytotoxicity in Glioblastoma Cell Lines with Normal or Deficiency in DNA-dependent Protein Kinase Activity. Pediatr Neonatol. 2012; 53(3), 199-204. (SCI, IF 1.231, ranking 76/119=63.9% in Pediatrics) 18. Yi Fan Lan#, His Hsien Chen#, Pei Fang Lai, Ching Feng Cheng, Yen Ya Huang, Yi Chao Lee, Tzen Wen Chen, Heng Lin: MicroRNA-494 Reduces ATF3 Expression and Promotes AKI. J Am Soc Nephrol. 2012; 23(12):2012-23. (SCI, IF 9.343, ranking 3/76=3.8% in Urology & Nephrology) 2013 19. Pei Chun Lai, Chuan Chu Cheng, Chia Chen Wu, Shih Hsin Hsu, Ted H. Chiu, Yen Ta Huang*: BDNF plus VEGF Additively Promotes Early Growth of the Transitional Cell Carcinoma Cell Line BFTC905 in vitro and in vivo. Tzu Chi Med J. 2013; 25 (3), 155-60. 2014 20. Yen Ta Huang, Chuan Chu Cheng, Tzu Chun Lin, Ted H. Chiu, and Pei Chun Lai: Therapeutic Potential of Sepantronium Bromide YM155 in Gemcitabine-resistant Human Urothelial Carcinoma Cells. Oncol Rep. 2014; 31(2):771-780. (SCI, IF 2.301, ranking 138/211=65.4% in Oncology) 21. Ying Chin Yang, Ming Che Lee, Yen Cheng Chen, Ted H. Chiu, Pei Chun Lai*,#, and Yen Ta Huang*,#: Decreased Protein Kinase D Expression in a Tissue Array of Hepatocellular Carcinoma Specimens. Oncol Lett. 2014 (Accepted) (SCI, IF 1.554, ranking 172/211 =81.5% in Oncology) 2015 22. Yen Ta Huang, Chuan Chu Cheng, Ted H. Chiu, and Pei Chun Lai: Therapeutic Potential of Thalidomide for Gemcitabine-resistant Bladder Cancer. Int J Oncol. 2015; 47 (5): 1711-1724. (SCI, IF 3.025, ranking 96/211=45.5% in Oncology) 23. Yen Ta Huang, Ying Chin Yang, Yu Hsien Lai, Chuan Chu Cheng, and Pei Chun Lai: Lactated Ringer, not Ringer’s Solution, Aggravates Ischemic-reperfusion Injury in a New Model Mimicking Hypovolemic Shock to HK-2 Human Proximal Renal Tubule Epithelial Cells in vitro. Ext Ther Med. 2015. (Accepted) (SCI, IF 1.269, ranking 97/123 =78.9% in Research & Experimental Medicine) 2016 24. Yen Ta Huang, Yi Ya Chen, Yu Hsien Lai, Chuan Chu Cheng, Ying Shih Su, Chin Hung Liu, and Pei Chun Lai: Resveratrol Ameliorated Radiocontrast

Ioxitalamate Induced Cytotoxicity through Reducing the Production of Reactive Oxygen Species in HK-2 Human Proximal Renal Tubule Epithelial Cells in vitro. Int J Mol Med. 2016; 37(1): 83-91. (SCI, IF 2.088, ranking 70/123 =56.9% in Research & Experimental Medicine)

Books 1. 胡勝川、黃彥達：急診醫學醫療手冊第二版，金名出版社。(2005) 2. 胡勝川、高偉峰、顏鴻章、楊久滕、張新、黃彥達：ACLS 精華第三版，金 名出版社。(2006) 3. 胡胜川、黄彦达：急诊医学医疗手册第二版，北京科学技术出版社。(2006) 4. 胡勝川、黃彥達：急診醫學醫療手冊第三版，金名出版社。(2007) 5. 胡勝川、黃彥達：急診醫學醫療手冊第四版，金名出版社。(2009) 6. 胡胜川、黄彦达：急诊手册，北京科学技术出版社。(2009) 7. 胡勝川、高偉峰、顏鴻章、楊久滕、張新、黃彥達、許智偉、賴佩芳、胡宇 慧、施美秀：ACLS 精華第四版，金名出版社。(2010) Posters1.黃彥達、郭健中、張新、胡勝川：2002 太魯閣馬拉松之傷病患特徵。 第二屆 亞洲急診年會 (2004) 2.黃彥達、郭健中、張新、胡勝川：高山肺水腫一案例報告。 民國 93 年台灣急 診醫學會學術研討會 (2004) 3.黃彥達、陳立光、胡勝川：台灣四十多年來未見的致死病例-狂犬病之病例報告。 民國 93 年台灣急診醫學會學術研討會 (2004) 4. Yen Ta Huang, S.H. Hsu, T.H.Chiu：BDNF promotes bladder tumor growth in SCID mice. Experimental Biology, San Francisco, USA (2006) 5. Yen Ta Huang, Sheng Chuan Hu：A Method to Improve the Efficiency of ED Consultations. ICEM 2006, Halifax, Canada. 6.Pei Chun Lai, Yen Ta Huang：Hints for Leptospirosis in ED. ICEM 2006, Halifax, Canada. 7.蔡銘仁、賴佩君、胡勝川、黃彥達：日本腦炎於急診之表徵：東台灣之經驗。 台灣急診醫學會學術研討會 (2006) 8.黃彥達、許世忻、吳佳真、藍逸帆、邱鐵雄：BDNF and TrkB Mediate Bladder Tumor Growth in SCID Mice. 第 15 屆細胞及分子生物新知研討會—墾丁冬令 營 (2007) 9.黃彥達、邱鐵雄：TrkB Blockade as a New Target for Transitional Cell Carcinoma Therapy. 第 25 屆生物醫學聯合學術年會(2010)

10.黃彥達、賴佩君、鄭全助、邱鐵雄：K252a and its analogue CEP-701 (lestaurtinib) exert potent cytotoxicity in P815 mastocytoma cells.第 25 屆生物醫學聯合學術年 會(2010) 11.黃彥達：TrkB Blockade as a New Target for Bladder Cancer Therapy. 東華大學 分子標靶與癌症治療研討會 (2010) 12. Pei Chun Lai, Yen Ta Huang, Chia Chen Wu, Chuan Chu Cheng, Ya Fan Lan, Ted H. Chiu: Tigecycline elicits cytotoxicity on trasitional cell carcinoma cellsin vitro.16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine, Rhodes Island, Greece. (2011) 13. Yen Ta Huang , Pei Chun Lai, Chia Chen Wu, Chuan Chu Cheng, Ted H. Chiu*: Preclinical evaluation of thalidomide for bladder cancer therapy. 16th World Congress on Advances in Oncology and 14th International Symposium on Molecular Medicine, Rhodes Island, Greece. (2011) 14. Yen Cheng Chen, Ming Che Lee, Ying Chin Yang, Chuan Chu Cheng, Ted H. Chiu, Pei Chun Lai *,#, Yen Ta Huang *,#：Therapeutic effects of YM155 on human cholangiocarcinoma cells.臺灣外科醫學會第 23 屆第一次會員代表大會暨第 71 次學術演講會(2012) 15. Yen Ta Huang, Ming Che Lee, Yen Cheng Chen, Chuan Chu Cheng, Ted H. Chiu , Pei Chun Lai*,#, Ying Chin Yang*,#: Novel survivin inhibitor YM-155 combined with rapamycin as a potential therapy for recurrent hepatocellular carcinoma after liver transplantation. 24th International Congress of the Transplantation Society. (2012) 16. Yen Ta Huang, Ming Che Lee, Ying Chin Yang, Ta Sen Yeh, Chuan Chu Cheng, Tzu Chun Lin,Ted H. Chiu, Pei Chun Lai, Yen Cheng Chen: Therapeutic effects of Tropomyosin-related kinase B (TrkB) blockade on cholangiocarcinoma cells. 102 年度外科聯合學術演講會 (2013) 17. Yen Ta Huang, Lee Ying Soo, Guan Jin Ho, Chuan Chu Cheng, Ted H. Chiu, Pei Chun Lai: Different Effects of 0.9% NaCl, lactated Ringer, and Ringer’s solution on activated human proximal renal tubule cells in vitro. The 41st Annual meeting of Japanese Society of Intensive Care Medicine (JSICM), the 14 th Joint Scientific Congress of JSICM and KSCCM, and the International Scientific Congress of Intensive Care and Critical Care Medicine, Kyoto, Japan (2014). 18. Yen Ta Huang, Chuan Chu Cheng, Tzu Chun Lin, Pei Chun Lai: Elocalcitol ameliorates toxicity of lactated Ringer in HK-2 human renal proximal tubule cells in hypovolemia mimicking model. 34th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium. (2014) 19. Yi Ya Chen, Chuan Chu Cheng, Tzu Chun Lin, Yen Ta Huang*: Resveratrol ameliorates apoptosis induced by contrast medium ioxitalamate in HK-2 human

renal proximal tubule cells in vitro. 34th International Symposium on Intensive Care and Emergency Medicine, Brussels, Belgium. (2014)