USO0RE43978E

(19) United States (12) Reissued Patent

(10) Patent Number:

Holm-Kennedy (54)

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4/1984 Zommer 9/1988

Purbrick 61:11.

4,794,441 A

12/ 1988 SugaWara et al.

4,885,623 A 4,916,505 A

12/1989 Holm-Kennedy et a1. 4/1990 Holm-Kennedy

4,922,315

A

5/1990

4,926,682 A

C almer-

*Feb. 5, 2013

7/1982 Nakamura et a1‘

4,773,970 A

AssIgnee: University of HaWaII, Honolulu, HI ~

12/1980

4,441,117 A _

(US) *

7/1976 Fulkerson 4/1980 Plummer

4,339,765 A

) _

( ) Not1ce.

3,970,866 A 4,199,774 A 4,238,757 A

Jsgles W. Holm Kennedy, Honolulu, HI

_

(73)

(45) Date of Reissued Patent:

ULTRASENSITIVE BIOCHEMICAL SENSOR

(75) Inventor.

US RE43,978 E

Vu

5/l990 Holm_Kennedy et 31‘

4,926,693 A

5/1990 Holm-Kennedy etal.

4,951,510 A

8/1990 Holm-Kennedy et a1.

(21)

Appl.NO.Z 12/284,606

4,960,177 A

10/1990 Holm-Kennedy et a1.

5,036,286 A

7/1991 Holm-Kennedy et a1.

(22)

Filed;

5,083,466 A

1/1992 Holm-Kennedy et a1.

sep_ 23, 2008

Related US. Patent Documents

2215511;atent 017 No.:

isuidliq pp .

(Commued)

7 , 291 , 496

FOREIGN PATENT DOCUMENTS

?ag-53’ $37 o.:

JP

55-010546

1/1980

JP

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U~S~ Applicationsl (60) Provisional application No. 60/516,485, ?led on Oct.

OTHER PUBLICATIONS

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31, 2003, provisional application NO_ 60/473,202,

Parke, S.,eta1.“Aversatile, SOI BiCMOS TechnologyWith Comple

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G01N 33/551 (52)

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436/518;_ 436/524; 436/527; 436/149; 436/806 _

(58)

Primary Examm” * Chris L Chin

_ Field of Classi?cation Search ...................... .. None

(57)

See application ?le for Complete Search history

An electromc sensor 1s prov1ded for detectlng the presence of

References Cited

preferably comprises a ?eld effect transistor in Which con

U.S. PATENT DOCUMENTS

tors in the active region. An array of sensors may be formed to

_

_

ABSTRACT _

_

one or more analytes of interest in a sample. The sensor

(56)

ductance is [enhanced] altered by analyte binding to recep 2,913,676 A

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6/1961 RutZ

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analyze a sample for multiple analytes. 48 Claims, 25 Drawing Sheets

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Y 9 YWYYH'YVHWEV‘; it‘ Y

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Kumar, M. et al. A Simple, High Performance TFSOI Complemen '

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IEEE Transactions on Electron Devices, vol. 489, No. 1 (Jan 2002) ;;. ZOO-202

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