CONFERENCE PROGRAM PRE-MEETING: FRIDAY, MAY 30, 2014 The Role of Mitochondria in Aging
Organizers: Yidong Bai and Holly Van Remmen
Room: Navarro B
8:00 AM - 8:30 AM
Pre-Conference Registration and Continental Breakfast
8:30 AM - 8:45 AM
Opening Comments Yidong Bai, The University of Texas Health Science Center at San Antonio and Holly Van Remmen, Oklahoma Medical Research Foundation Mitochondrial Function and Synaptic Plasticity in Brain Aging and a Mouse Model of Alzheimer’s Disease Enrique Cadenas, University of Southern California Rethinking the Cellular Targets of Mitochondrial Dysfunction Associated with Aging Carlos Moraes, University of Miami
8:45 AM - 9:20 AM
9:20 AM - 9:55 AM
9:55 AM - 10:20 AM
BREAK
10:20 AM - 10:55 AM
Mitochondrial Protein Acetylation Eric Verdin, University of California at San Francisco Direct Regulation of Cupins by the Metabolic Network in the C. Elegans Mit Mutants Shane Rea, The University of Texas Health Science Center at San Antonio
10:55 AM - 11:30 AM
11:30 AM - 1:00 PM 1:00 PM - 1:35 PM 1:35 PM - 2:10 PM
2:10 PM - 3:00 PM
3:00 PM - 3:15 PM
LUNCH ON YOUR OWN Comparative Bioenergetic Study of Neuronal and Muscle Mitochondria During Aging Yidong Bai, The University of Texas Health Science Center at San Antonio Communication Between the Mitochondrion and the Nucleus in Aging and Age-Related Disease S. Michal Jazwinski, Tulane University A Mitochondrial Etiology of Metabolic and Degenerative Diseases, Cancer and Aging Douglas Wallace, Children’s Hospital of Philadelphia Closing Remarks PRE-MEETING ADJOURNS
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MEETING: FRIDAY, MAY 30, 2014
Slowing Aging: Signaling, Stress Resistance, Stem Cells, and Small Molecules, Insights from Old and New Models Opening Panel Room: Navarro A
6:30 PM - 7:45 PM
Opening Address Rochelle Buffenstein, The University of Texas Health Science Center at San Antonio Panel Discussion: Increasing Healthspan: Science and Policy on the Path to Healthier Aging Chair: Janko Nikolich-Žugich. Panelists: Felipe Sierra, National Institute on Aging, Eleanor Simonsick, National Institute on Aging, Jay Olshansky, University of Illinois at Chicago and Susan Peschin, Alliance for Aging Research
7:45 PM - 8:00 PM
Awards Presentation David Stipp, Edward Masoro, and Huber Warner
Opening Reception
8:00 PM - 9:30 PM
Room: Navarro B Reception and Silent Auction
SATURDAY, MAY 31, 2014 Key Note Address
7:30 AM - 8:10 AM 8:10 AM - 9:15 AM
Room: Navarro A Continental Breakfast Introduced by Rochelle Buffenstein Key Note Address: Molecular Mechanisms that Regulate Mammalian Aging Toren Finkel, National Heart, Lung, and Blood Institute, National Institutes of Health
Session 1: Stem Cells and Aging
9:15 AM - 9:20 AM
9:20 AM - 9:40 AM 9:40 AM - 10:00 AM 10:00 AM - 10:20 AM 10:20 AM - 10:40 AM 10:40 AM - 11:00 AM
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Room: Navarro A Opening Comments Chairs: Vivienne Rebel, The University of Texas Health Science Center at San Antonio and Jacob Hemmi, The University of Texas Health Science Center at San Antonio 1. Division, Differentiation, and Maintenance of Adult Neural Stem Cells Grigori Enikolopov, Cold Spring Harbor 2. Induced Pluripotent Stem Cells in Marmosets and Other Novel Models Jacob Hemmi, The University of Texas Health Science Center at San Antonio 3. Aging of Hematopoietic Stem Cells; A Single Cell Perspective Gerald de Haan, University Medical Center Groningen 4. The Aging Neural Stem Cell Environment Erzsebet Kokovay, The University of Texas Health Science Center at San Antonio Panel Discussion
11:00 AM - 11:20 AM
BREAK
Session 2: Age-Related Changes in Proteolytic Pathways and Proteostasis Room: Navarro A
11:20 AM - 11:25 AM
12:45 PM - 1:05 PM
Opening Comments Chairs: Maria Figuiredo-Pereira, Hunter College, City University of New York and Kelly Grimes, The University of Texas Health Science Center at San Antonio 5. Link Between Inflammation and the Ubiquitin-Proteasome Pathway in Parkinson’s Disease Maria Figuiredo-Pereira, Hunter College, City University of New York 6. Inter-cellular Propagation of Huntingtin Aggregation in the Drosophila Central Nervous System Maggie Pearce, Stanford University 7. Role of the Proteasome and its Regulators in Stress Adaptation & Ageing Kelvin J. A. Davies, University of Southern California 8. Autophagy and Cardiac Aging Roberta Gottlieb, Cedars-Sinai Medical Center Panel Discussion
1:05 PM - 2:20 PM
LUNCH ON YOUR OWN
1:05 PM - 2:20 PM
AGE JOURNAL EDITORIAL BOARD MEETING Room: Zapata
11:25 AM - 11:45 AM
11:45 AM - 12:05 PM
12:05 PM - 12:25 PM 12:25 PM - 12:45 PM
Session 3: Circadian Dysregulation in Aging, Consequences and Causes Room: Navarro A
2:20 PM - 2:25 PM
3:45 PM - 4:05 PM
Opening Comments Chairs: Jaga Giebultowicz, Oregon State University and Miranda Orr, The University of Texas Health Science Center at San Antonio 9. Biological Clocks, Feeding Regimes and Aging Roman Kondratov, Cleveland State University 10. Influence of Aging on Clock Gene Expression in Hamsters Marilyn Duncan, University of Kentucky 11. Circadian Regulation, Chronic Inflammation and Aging Marina Antoch, Roswell Cancer Institute 12. Aging Clocks, Aging Bodies: Correlation or Causation? Jaga Giebultowicz, Oregon State University Panel Discussion
4:05 PM - 4:25 PM
BREAK
2:25 PM - 2:45 PM 2:45 PM - 3:05 PM 3:05 PM - 3:25 PM 3:25 PM - 3:45 PM
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Session 4A: Oral Presentations Chosen From Selected Abstracts Room: Navarro A
4:25 PM - 4:30 PM 4:30 PM - 4:45 PM
4:45 PM - 5:00 PM
5:00 PM - 5:15 PM
5:15 PM - 5:30 PM 5:30 PM - 5:45 PM
Opening Comments Chair: James F. Nelson, The University of Texas Health Science Center at San Antonio 13. The Newly Discovered Aging Gene: FAT10, Provides an Insight into the Impact of Inflammation on Metabolism and Obesity Allon Canaan, Yale University 14. A Multi-Organism Approach to Identify Novel Evolutionarily Conserved Aging Factors George Sutphin, The Jackson Laboratory 15. The Phosphatase Calcineurin β Protects Astrocytes by Increasing Autophosphorylation of PKR-like Endoplasmic Reticulum Kinase Yanan Chen, The University of Texas Health Sciences Center at San Antonio 16. Using Embryonic Stem Cells to Identify Stress Resistance Genes in the Mouse Wallace Chick, The University of Colorado Denver Panel Discussion
Session 4B: Oral Presentations Chosen From Selected Abstracts Room: Navarro B
4:25 PM - 4:30 PM 4:30 PM - 4:45 PM
4:45 PM - 5:00 PM 5:00 PM - 5:15 PM
5:15 PM - 5:30 PM
5:30 PM - 5:45 PM 5:45 PM - 7:45 PM
Opening Comments LaDora V. Thompson, University of Minnesota 17. Hippocampal Subregions Exhibit Both Distinct and Shared Transcriptomic Responses to Aging and Non-Neurodegenerative Cognitive Decline Dustin Masser, The University of Oklahoma Health Sciences Center 18. Composition of Dietary Fatty Acid Intake Alters the Efficacy of Rapamycin Treatment Adam Salmon, The University of Texas Health Sciences Center at San Antonio 19. The Changing Landscape of Poly-Ubiquitin Mediated Homeostasis in Aging, Calorie Restriction, and Rapamycin Treatment Nathan Basisty, University of Washington 20. Developmental Programming by Maternal Obesity in Pregnancy and Lactation Accelerates Age-Related Changes in Liver Antioxidant Systems and Oxidative Stress in Male Rat Offspring Peter W. Nathanielsz, The University of Texas Health Sciences Center at San Antonio Panel Discussion POSTER SESSION AND RECEPTION Room: Navarro Pre-Function
Student Data Blitz & Fiesta
Hosted by James F. Nelson and Rafael de Cabo 6:00 PM - 7:30 PM 7:45 PM - 9:30 PM
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Data Blitz Presentations Room: Zapata Student Party Home of James F. Nelson, 104 Adams Street, San Antonio, TX 78210
SUNDAY, JUNE 1, 2014 7:30 AM - 8:00 AM
Continental Breakfast
Session 5: Stress Resistance and Signaling; Key Indicators of Longevity Room: Navarro A
8:00 AM - 8:05 AM
9:25 AM - 9:45 AM
Opening Comments Chairs: Keith Blackwell, Harvard University and Kaitlyn Lewis, The University of Texas Health Science Center at San Antonio 21. A Role for the UPRmt in Counting Mitochondria. Do Old Cells Lose Count? Cole M. Haynes, Memorial Sloan-Kettering Cancer Center 22. Molecular Mechanisms of the Pro-longevity Response to Mitochondrial ROS in C. Elegans Siegfried Hekimi, McGill University 23. Deciphering DAF-16/FoxO Transcriptional Networks to Understand Ageing in C. Elegans. BSRA Korenchevsky Jennifer Tullet, University College of London 24. How SKN-ny Worms Avoid Wrinkles Keith Blackwell, Harvard University Panel Discussion
9:45 AM - 10:05 AM
BREAK
8:05 AM - 8:25 AM 8:25 AM - 8:45 AM
8:45 AM - 9:05 AM
9:05 AM - 9:25 AM
Session 6: Teaching Old Models New Tricks Room: Navarro A
10:05 AM - 10:10 AM
10:10 AM - 10:30 AM 10:30 AM - 10:50 AM 10:50 AM - 11:10 AM
11:10 AM - 11:30 AM 11:30 AM - 11:50 AM 11:50 AM - 12:10 PM
Opening Comments Chairs: Ken Storey, Carleton University and Olav Rueppell, The University of North Carolina at Greensboro 25. Aging Plasticity, Stress, and Social Behavior in the Honey Bee Model Olav Rueppell, The University of North Carolina at Greensboro 26. Comparative Biology of Cytoprotective Regulation and its Role in Rodent Longevity Kaitlyn Lewis, The University of Texas Health Science Center at San Antonio 27. Molecular Adaptations of Mammalian Hibernation; Links Between Metabolic Depression and Aging Michael Wu, Carleton University 28. Warming Up to Heat Shock Proteins in Determining Healthspan! Kylie Kavanagh, Wake Forest School of Medicine 29. Forever Young, What Turtles Can Tell Us About Aging Ken Storey, Carleton University Panel Discussion
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12:10 PM - 1:30 PM
DENHAM HARMAN AWARD LECTURE AND LUNCHEON Introduction by Holly Brown-Borg From Free Radicals to the Aging Heart: it’s not the Destination but the Journey Peter Rabinovitch, MD, PhD
Session 7: The Forgotten ‘Ome, Small Molecules in Aging Room: Navarro A
1:30 PM - 1:35 PM
2:55 PM - 3:15 PM
Opening Comments Chairs: Shane Rea, The University of Texas Health Science Center at San Antonio and Erin Munkacsy, The University of Texas Health Science Center at San Antonio 30. Metabolomics of Aging in the Common Marmoset Dean P. Jones, Emory University 31. The Chemical Language of Worms: How Small-Molecule Sensing Controls Aging Frank Schroeder, Cornell University 32. Uncovering the Mechanisms of a Novel Peptide Encoded in the Mitochondrial Genome: Navigating with a Metabolomics Map Changhan David Lee, University of Southern California 33. Global Metabolomics Provides Insights on Aging Pathways and Disease Management Lining Guo, Metabolon Panel Discussion
3:15 PM - 3:35 PM
BREAK
1:35 PM - 1:55 PM 1:55 PM - 2:15 PM 2:15 PM - 2:35 PM
2:35 PM - 2:55 PM
Session 8: Molecular Chaperones and Aging Room: Navarro A
3:35 PM - 3:40 PM
3:40 PM - 4:00 PM 4:00 PM - 4:20 PM 4:20 PM - 4:40 PM 4:40 PM - 5:00 PM 5:00 PM - 5:45 PM 5:45 PM - 7:30 PM 7:00 PM - 9:00 PM
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Opening comments Chairs: Karl Rodriguez, The University of Texas Health Science Center at San Antonio and Martin Hetzer, Salk Institute for Biological Studies 34. Pontin and Reptin - Novel Chaperones in the Aggresome Pathway? Michael Sherman, Boston University 35. The Role of Long-Lived Proteins in Aging Martin Hetzer, Salk Institute for Biological Studies 36. Novel Age-Related Mechanisms for Heat Shock Protein Transcription Heeyoun Bunch, Harvard University Panel Discussion AGE MEMBERSHIP MEETING Room: Navarro AB POSTER SESSION AND RECEPTION Room: Navarro Pre-Function AGE BOARD OF DIRECTORS MEETING Room: Zapata
MONDAY, JUNE 2, 2014 Session 9: The Gut Microbiome and its Role in Immunity, Inflammation and Aging Room: Navarro A
8:00 AM - 8:05 AM
9:25 AM - 9:45 AM
Opening Comments Chairs: Molly Bergman, The University of Texas Health Science Center at San Antonio and Holly Brown-Borg, University of North Dakota 37. Using Resistant Starch to Improve Healthspan via Changes in Gut Microbiota and Fermentation Roy Martin, Western Human Nutrition Research Center 38. Genomic Studies of the Human Microbiome and Disease George Weinstock, Jackson Laboratory for Genomic Medicine 39. The Age Effect on Gut Microbiota-Triggered Autoimmunity Joyce Wu, Arizona University College of Medicine 40. Age-Related Decline of Regeneration and Proliferative Homeostasis: Lessons from Drosophila Heinrich Jasper, The Buck Institute for Research on Aging Panel Discussion
9:45 AM - 10:05 AM
BREAK
8:05 AM - 8:25 AM
8:25 AM - 8:45 AM 8:45 AM - 9:05 AM 9:05 AM - 9:25 AM
Session 10A: Nathan Shock Symposium Room: Navarro B
10:05 AM - 10:15 AM 10:15 AM - 10:35 AM
10:35 AM - 10:55 AM
10:55 AM - 11:15 AM
11:15 AM - 11:35 AM
11:35 AM - 11:55 AM 11:55 AM - 12:15 PM
2015 Renewal of Nathan Shock Centers Chair: Felipe Sierra, National Institute on Aging 41. Improving Cardiac Healthspan by Interventions that Enhance Mitochondrial Function Ying Ann Chiao, University of Washington 42. A Strange Case of Immune Suppression: Rapamycin’s Effects on Immunity During Aging Adriana Benavides, The University of Texas Health Science Center at San Antonio 43. Emerging Strategies in the Genetics of Aging: The Jackson Laboratory Nathan Shock Center on Aging Kevin Flurkey, The Jackson Laboratories 44. Identification of Neurosensory Mechanism for Dietary Protein by Drosophila Melanogaster Jennifer Ro, University of Michigan 45. Hypothalmic Inflammation in Aging and Lifespan Control Dongsheng Cai, Yeshiva University Panel Discussion
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Session 10B: Translational Medicine to Improve Healthy Aging Room: Navarro B
10:05 AM - 10:10 AM
10:10 AM - 10:30 AM
10:30 AM - 10:50 AM 10:50 AM - 11:10 AM
11:10 AM - 11:30 AM 11:30 AM - 11:50 AM
Opening Comments Chairs: Nick Musi, The University of Texas Health Science Center at San Antonio and Sangeeta Ghosh, The University of Texas Health Science Center at San Antonio 46. Stem Cell Approaches to Understanding and Treating Neurodegenerative Diseases of Aging Larry Goldstein, University of California, San Diego 47. Harnessing the Mitochondrial Peptidome to Address Aging and Related Diseases Pinchas Cohen, University of Southern California 48. Fiber Type-Specific Muscle Stem Cell Response to Aerobic Training in Sedentary Adults Charlotte A. Peterson, University of Kentucky 49. Role of NFkB on Aging-Related Pathologies Nick Musi, The University of Texas Health Science Center at San Antonio Panel Discussion
Session 11: Special Lecture - James Joseph Address Room: Navarro A
12:15 PM - 12:20 PM 12:20 PM - 1:05 PM
1:05 PM - 1:20 PM
Opening Comments Chair: R. Michael Anson, The Community College of Baltimore County 50. Dietary Polyphenols for Healthy Aging: Evidence from Human Intervention Studies Ana Rodriguez-Mateos, University of Dusseldorf AWARD CEREMONY: FELLOWS AND STUDENT AWARDS Room: Navarro A MEETING ADJOURNS
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