TX Primary tumor cannot be assessed (for example, curettaged or severely regressed melanoma) T0 No evidence of primary tumor Tis Melanoma in situ T1 Melanomas 1.0 mm or less in thickness T2 Melanomas 1.01–2.0 mm T3 Melanomas 2.01–4.0 mm T4 Melanomas more than 4.0 mm NOTE: a and b subcategories of T are assigned based on ulceration and number of mitoses per mm2, as shown below: ULCERATION STATUS/MITOSES
T1
≤1.0
a: w/o ulceration and mitosis <1/mm2 b: with ulceration or mitoses ≥1/mm2
T2
1.01–2.0
a: w/o ulceration b: with ulceration
T3
2.01–4.0
a: w/o ulceration b: with ulceration
T4
>4.0
a: w/o ulceration b: with ulceration
M CLASSIFICATION
M1a M1b M1c
Stage 0 Stage IA Stage IB
N CLASSIFICATION
Stage IIC Stage III
N2
N3
1 node
Distant skin, subcutaneous, or nodal mets Lung metastases All other visceral metastases Any distant metastasis
a: micrometastasis1 b: macrometastasis2 c: in transit met(s)/satellite(s) without metastatic nodes 4 or more metastatic nodes, or matted nodes, or in transit met(s)/satellite(s) with metastatic node(s)
IIIC
Stage IV
Any T
Any N
M1
IV
Pathologic Staging4 Tis N0 T1a N0 T1b N0 T2a N0 T2b N0 T3a N0 T3b N0 T4a N0 T4b N0 T1-4a N1a T1-4a N2a T1-4b N1a T1-4b N2a T1-4a N1b T1-4a N2b T1-4a N2c T1-4b N1b T1-4b N2b T1-4b N2c Any T N3 Any T Any N
Notes 1 Micrometastases are diagnosed after sentinel lymph node biopsy and completion lymphadenectomy (if performed). 2 Macrometastases are defined as clinically detectable nodal metastases confirmed by therapeutic lymphadenectomy or when nodal metastasis exhibits gross extracapsular extension. 3 Clinical staging includes microstaging of the primary melanoma and clinical/radiologic evaluation for metastases. By convention,
Financial support for AJCC 7th Edition Staging Posters provided by the American Cancer Society
it should be used after complete excision of the primary melanoma with clinical assessment for regional and distant metastases. 4 Pathologic staging includes microstaging of the primary melanoma and pathologic information about the regional lymph nodes after partial or complete lymphadenectomy. Pathologic Stage 0 or Stage IA patients are the exception; they do not require pathologic evaluation of their lymph nodes.
Printed with permission from the AJCC.
NX Patients in whom the regional nodes cannot be assessed (for example, previously removed for another reason) N0 No regional metastases detected N1-3 Regional metastases based upon the number of metastatic nodes and presence or absence of intralymphatic metastases (in transit or satellite metastases) NOTE: N1–3 and a–c subcategories assigned as shown below: N1
SERUM LDH
A N AT O M I C S TAG E / P R O G N O S T I C G R O U P S
Regional Lymph Nodes (N)
NO. OF METASTATIC NODES
SITE
•
THICKNESS (mm)
M0 No detectable evidence of distant metastases M1a Metastases to skin, subcutaneous, or distant lymph nodes M1b Metastases to lung M1c Metastases to all other visceral sites or distant metastases to any site combined with an elevated serum LDH NOTE: Serum LDH is incorporated into the M category as shown below:
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Sep 28, 2006 - The most notable of the prior studies was the analysis of the American Joint Committee on. Cancer's melanoma database of more than 16,000 patients, which led to ... With respect to control of regional disease, patients in the observati
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May 18, 2008 - John L Hopper7, Nicholas G Martin2, Jeffrey M Trent20,. Graham J Mann5 & Nicholas K Hayward2. We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,10
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the U.S. Food and Drug Administration (FDA) for the treat- ment of metastatic ... dent that the complex physiological network of ABC trans- porters has a pivotal role in host .... (XAF1) has been identified using two hybrid system [67]. XAF1 was ....
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toxicity resulting in increased numbers of hospital admis- sions. Immunotherapy continues to be evaluated in metas- tatic disease such as interferon (IFN)-alpha ...
histopathology of malignant melanoma in the 1930s. (and in every subsequent decade), it is fair to conclude that criteria for morphologic diagnosis of melanoma. (and of other disorders) are a work in progress. Particularly strong progress was made in
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vine serum albumine (BSA) (SIGMA). The tumour cell suspen- sions were washed in DMEM + 10% fetal bovine serum (FBS). (Gibco) and passed through a 100 ...
Available online 22 February 2007. Keywords: Melanoma .... tion which has been found to be the best tool to screen the uniqueness of DNA profiles in a ..... Whether other neuroectodermal derived tumours share sim- ilar properties remains to ...
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Dec 3, 2008 - 1Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive,. SRB 24016, Tampa, FL 33612, USA; 2Department of Surgery, University of South Florida College of Medicine, Tampa,. FL, USA; 3D