Product Data Sheet Recombinant Human GDNF

Catalog Number: 100-02

Product Description_____________________________________________________________________ Alternate Names: ATF-1 Accession Number: P39905 Description: Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons. Source: Genetically modified E.coli. Predicted MW: Dimer, 15.2/30.4 kDa (with 135/270 amino acids) AA Sequence: MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN RRLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI

Formulation: Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 10 mM sodium citrate, 100 mM sodium chloride, pH 4.0

Product Specifications*__________________________________________________________________ *Lot-specific values for the following specifications are supplied with each production lot on its corresponding COA.

Specification Purity Endotoxin Biological Activity

Method of Determination Reducing and Non-Reducing SDS-PAGE Kinetic LAL (50% confidence) C6 proliferation

Acceptance Criteria ≥ 95% ≤ 1 EUs/µg ED50 ≤ 3 ug/mL (≥ 3.3 x 10^2 units/mg)

Product Preparation and Storage__________________________________________________________ Country of Origin: USA Shipping: Room temperature Storage Prior to Reconstitution: -20°C Product Reconstitution: Sterile water at 0.1 mg/mL Instructions: Centrifuge vial before opening. Suspend the product by gently pipetting the above recommended solution down the sides of the vial. DO NOT VORTEX. Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80°C and avoid repeat freeze thaws. Expiration Date: 12 months from date of receipt when stored at -20°C to-80°C as supplied. 1 month when stored at 4°C after reconstituting as directed. 3 months when stored at -20°C to -80°C after reconstituting as directed. THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS!

Human GDNF Data Sheet 100-02.pdf

THIS PRODUCT IS FOR RESEARCH USE ONLY AND IS NOT FOR USE IN HUMANS! Page 1 of 1. Human GDNF Data Sheet 100-02.pdf. Human GDNF Data ...

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