(BPH70112)

3.

Explain in detail about the Protein-Bindin.g of the drugs. Derive the equations involved in kinetics of , protein binding.

Or

4.

Explain about the various pathways of drug metabolism (Phase-I and ~hase-II)

5.

Discuss in detail about the l-compartment-open­ Oral Administration and its Parameters.

B.Pharmacy DEGREE- EXAMINATION, NOVEMBER 2016. (Regular/Supplementary) . Seventh Semester

Paper I - : PHARMACEUTICS-III

(BIOPHARMACEUTICS, PHARMACOKINETICS AND

NEW DRUG DELIVERY SYSTEMS)

(Regulation 2012-2013) Maximum: 70 marks

Time : Three hours

Or 6.

Explain in detail about the Non-Linear kinetics. Write a note on Michel-Manton Constant.

"7.

Explain about the concepts, preparations and dosage calculations involved in Sustain Release Products, Or

8.

Explain in detail about design and' evaluation of Parentral and Implantable products.

9.

Discuss. in detail about the various techniques involved in Microencapsulation?

Or

10.

Explain about the drug loading methods in .resealed-erythrocytes. Write note on Niosome and its applications.

Answer ALL the questions. All questions carry the equal marks. (5 x 14 = 70) 1.

Explain about the drug transport mechanisms. What are the various routes of drug administration and their limitations? Or

2.

Discuss in detail about the various biological factors affecting the drug absorption. Write note on pre-systemic.metabolism?

2

(BPH70112)

(BPH70312) B.Pharmacy DEGREE EXAMINATION,

NOVEMBER 2016.

Seventh Semester

(Regular/Supplementary)

Paper II

~

PHARMACOLOGY - II

(Regulation 2012-13)

Time : Three hours

Maximum: 70 marks

Answer ALL questions.

All questions carry equal marks.

(5 x 14 1.

2.'

= 70)

(a)

Explain the pathophysiology of hyperlipidemia in detail and write the classification of antihyperlipidemic .agents? (10)

(b)

Write a note or! haematinics. Or

(4)

(a)

Anti arrhythmic agents.

(7)

(b)

Drugs used in the management of angina .. pectoris. (7)

3.

(a)

(b)

4.

5.

Explain the patho physiology of COPD in detail and write the classification of bronchodilators. (10) Write a note on Mucolytics. Or

9.

(4)

Discuss in detail about eicasanoids pathway and their physiological role, and classify their inhibitors. . (14) Classify anti cancer agents and mechanism of action, adverse effects.

write

the

Write about following: (a)

General treatment of poisoning,

(b)

Oragano phosphorus poisoning and their treatment. (7)

(7)

Or 10.

Define bio-assay, write the types, factors influencing . the bio-assay, advantages and (14) disadvantages.

(14)

Or 6.

(a)

Classify antiviral agents arid write the mechanism of action, adverse effects. (10)

(b)· Write a note on antiprotozoal drugs.

(4)

7.

Explain the pathophysiology of diabetes mellitus in detail and write the classification of anti diabetic agents, mechanism of action, adverse effects. (14) . Or

8.

Write about the following: (a)

Posterior pituitary hormones.

(7)

(b)

Oral contraceptives.

(7)

2

(BPH70312)

3

(BPH70312)

(BPH70512) B.Pharmacy. DEGREE EXAMINATION,

NOVEMBER 2016.

Seventh Semester

(Regular /Supplementary)

Paper III -

PHARMACEUTICAL ANALYSIS - II

(Regulation 2012-2013)

Maximum: 70 marks

Time : Three hours

'Answer ALL questions. All questions carry equal marks. (5 x 14 1.

= 70)

Define Beer's - Lambert's law' and derive its mathematical equation. Explain in detail instrumentation and applications of Spectrophotometry? Or

,2.

(a)

Explain the theory and principle behind Fluorimetric analysis and add a note on quenching? (6)

(b)

Draw a line diagram of spectrofluorometer and' explain the functions of its compone.nts. (8)

3.

Give the principle involved in Conductometry. Explain different types of conductometric titrations and its applications.

8.

(b)

Or 4.

What is the principle involved in Polarography? Note on different types of currents in polarography. Write about the procedure for analysis with a neat diagram and give its applications.

9.

Explain" the principle and methodology of TLC. Make a detailed note on its practical requirements, highlighting the preparation and activation of TLC plates. and detection methods. Mention its applications.

Give the principle and methodology in ­ "HPTLC. (7) Explain the electrophoresis distribution.

principles involved In and coulter current " (7)

Write in detail principle, theory, instrumentation and applications of DTA?

Or 10.

5.

(a)

What is Radio Immune Assay? Give the requirements and procedure for carrying out RIA. Add a.note on its applications.

Or 6.

Explain the principle involved in GAS chromatography. Write about its Instrumentation making·a special note on Detectors used. Give its applications.

7.

Explain the principle and different analytical parameters in HPLC making a special note on Van Deemter's equation. With" a neat schematic diagram explain various' components of the instrument.

Or 2

(BPH70512)

3

(BPH70512)

· (BPH70712)­

5.

B.Pharmacy DEGREE EXAMINATION,

NOVEMBER.2016.

(Regular/Supplementary)

Or 6.

Seventh Semester

Paper IV - INDUSTRIAL MANAGEMENT AND

PHARMACEUTICAL MARKETING

7.

(Regulation 2012-13)

Time : Three hours

Maximum: 70 marks'

1.

2. 3.

4.

(5x14 = 70) What do .you understand by the words "Administration" and "Management". Briefly mention about Administration. Or Enumerate the functions of Management. Draw' an Ideal Lay' out of .a Retail Drug Store and discuss.

Or

Discus's the various Legal Requirements to be fulfiled to open a Retail Drug Store.

Explain the following: (a)

Scientific Purchasing.

(b)

Quality Control

Write about: (a)

Wholesale Trade

(b)

Retail Trade.

Or

Answer ALL. the following.

All questions carry equal marks.

What are the functions of Production Planning and Control? Explain the procedure with applications.

8.

What do .you understand by "Market Research". How it is conducted? What benefits are derived from it?

9.

Define Accounting. What are the main objectives of Accounting?

Or 10. Distinction between Trial Balance and Balance Sheet..

2

(~PH70712)